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Effective monitoring of key antigen changes in RBD and early response to immune escape caused by it are of important scientific significance
The study found that most of the neutralizing antibodies mainly recognize the first and second type epitopes; while the neutralizing antibodies that can cross-bind SARS-CoV-2 and SARS-CoV mainly recognize the third and fourth types of epitopes.
Researcher Sun Bing, Professor Lu Hongzhou, Professor Xie Youhua and Associate Researcher Ling Zhiyang are the co-corresponding authors of this article
The receptor binding domain of the new coronavirus spike glycoprotein is a key site that mediates the binding of the virus to the host cell ACE2 receptor, and is also a key target for neutralizing antibodies and vaccines
.
Effective monitoring of key antigen changes in RBD and early response to immune escape caused by it are of important scientific significance
Based on previous work, the researchers isolated 93 RBD-specific antibodies from people who have recovered from the new coronavirus infection and combined with the reported antibodies.
Using alanine scanning and epitope competition experiments, the protective epitopes on RBD were systematically Divided into four categories
.
The study found that most of the neutralizing antibodies mainly recognize the first and second type epitopes; while the neutralizing antibodies that can cross-bind SARS-CoV-2 and SARS-CoV mainly recognize the third and fourth types of epitopes.
Yi Chunyan and Sun Xiaoyu, postdoctoral fellows of the Sun Bing Research Group of the Center of Molecular Cellular Excellence, Dr.
Lin Yixiao from the Lu Hongzhou team of the Public Health Clinical Center of Shanghai (Affiliated to Fudan University), and Gu Chenjian, a postdoctoral fellow from the Xie Youhua team of School of Basic Medicine, Fudan University One author
.
Researcher Sun Bing, Professor Lu Hongzhou, Professor Xie Youhua and Associate Researcher Ling Zhiyang are the co-corresponding authors of this article
Article link: https://doi.
a.
