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| Sun Beicheng and Lin Anning's research team cooperate to reveal a new mechanism of liver cancer transformation regulation |
The latest results of the research team of Professor Sun Beicheng, Nanjing Gulou Hospital, Nanjing University School of Medicine, and Professor Lin Anning from the Institute of Modern Biology, Nanjing University, found that the transcription factor Miz1 protein in liver cells is independent of its transcriptional function, and has been combined with oncoproteins.
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide.
The latest research results of the research team of Sun Beicheng and Lin Anning proved that abnormal liver cell NF-κB activity, whether it is missing or increased, can induce inflammatory tumor microenvironment through different molecular mechanisms, thereby promoting the occurrence and development of liver cancer.
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Based on multi-omics analysis, this study used a variety of in vivo and in vitro experiments to reveal the specific mechanism by which Miz1 protein deletion in liver cells activates NF-κB and enhances inflammation through MTDH during the development of liver cancer, and proposes the liver as the main body of liver tumors.
The research results were published in the latest issue of the international authoritative academic journal Immunity with the title The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation .
The research results were published in the latest issue of the international authoritative academic journal Immunity with the title The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation .
The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation Immunity Academy of Sciences Zhang Wenjie Zhang Yuan Guangyan Wang Fei Sun Beicheng Lin Anning
