Summary of class 1 PD-1 drugs on the market and drugs under research in China

PD-1 (programmed cell death protein 1) is an important immunosuppressive molecule It is a member of CD28 superfamily It was originally cloned from the apoptotic mouse T-cell hybridoma 2b4.11 PD-1 as the target of immune regulation against tumor, anti infection, anti autoimmune diseases and organ transplantation survival are of great significance Its ligand PD-L1 can also be used as a target, and the corresponding antibody can also play the same role PD-1, as the most brilliant "anticancer drug" in the field of cancer treatment in recent years, has been approved more than 10 kinds of indications, which is the gospel of cancer patients The author specially collated the listed drugs and drugs under research of class 1 PD-1 in China, as shown in the table below The mechanism of action is as follows: PD-1 is mainly expressed in activated T cells, inhibiting the activation of cells, but tumor microenvironment can induce infiltrated T cells to express PD-1 molecules, tumor cells can express PD-L1 and PD-L2 ligands, which leads to the continuous activation of PD-1 pathway in tumor microenvironment, and the function of T cells is inhibited, unable to kill tumor cells PD-1 antibody can block this pathway, partially restore the function of T cells, so that these cells can continue to kill tumor cells For the drugs under research, we hope that they can be listed on the market and enter the Chinese market as soon as possible, treat and even cure cancer patients as soon as possible, and give them a bright future! Reference: Yaodu database