Summary: New ideas for building a responsive nano-diagnosis and treatment platform for tumor microcapic acid

cancer, or malignant tumor, is one of several major diseases that threaten human life and health. Despite decades of in-depth human research into the mechanisms and treatment of cancer, the increasing number of new cancer cases and high mortality rates remain significant challenges for existing cancer treatment methods. Therefore, the development of new cancer diagnosis and treatment methods to achieve safe and efficient tumor diagnosis and treatment has become one of the hot issues in many disciplines. The rapid proliferation of tumor cells, changes in metabolic pathways and incomplete and uneven distribution of tumor blood vessels cause the unique microenve environment of tumor tissue, which not only further induces the development and metastasis of tumors, but also seriously reduces the response of tumor tissue to conventional treatment methods.
years, the continuous development of nanotechnology has provided new ideas and possibilities for the construction of a new cancer diagnosis and treatment platform. Using the rich physicophysical properties of nanomaterials, the researchers designed a series of nano-diagnosis and treatment platforms with good tumor microencological responsiveness. Compared with traditional drug delivery systems and tumor contrast agents, these new nano-diagnosis and treatment platforms have better tumor targeting and significantly improved imaging signal-to-noise ratio, thus effectively improving the accuracy of tumor diagnosis and the selectivity and safety of treatment.
review article "The Acidic Tumor Microenvironment: A Target for Smart Smart Cancer Nano-theranostics", written by Professor Liu Zhuang of Suzhou University's Institute of Functional Nano and Soft Matter, was recently published in the National Science Review, 2017,
. This paper systematically summarizes the new ideas for the construction of tumor microic acid responsive nano-diagnosis and treatment platform in the field of nanomedical medicine, expounds the application of tumor microic acid responsive signal amplification strategy in tumor imaging imager design, and points out that this strategy can significantly improve the signal-to-noise ratio of imaging and further improve the accuracy of early diagnosis of tumor. The paper also points out that strategies such as charge reversal and particle size change of microic acid response surface can effectively improve the behavior of materials in tumor site, such as abunding, spreading and swallowing, and provide the possibility of safe and efficient treatment of tumor.
Liu Zhuang's team has been conducting research in the field of nanobiomaterials and nanomedicals for many years. With the goal of developing new functional nanomaterials, they study their behavior in life systems through structural design, controlled synthesis and reasonable surface modification, and develop new ideas and methods for cancer diagnosis and treatment by using the unique physical and chemical properties of nanomaterials to develop new multimode bioimaging technology, targeted drug delivery technology, and tumor physiotherapy technology. (Source: Science.com)