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Currently, a cutting-edge approach to cancer treatment that is exciting for scientists involves collecting and reprogramming a patient's T cells -- a specialized set of immune cells -- and then infusing them into the same patient, ready to detect and destroy cancer cells
immune immune leukemia _
Now, in a new study, researchers from Stanford University have developed a way to boost genetically modified immune cells -- called chimeric antigen receptor (CAR) T cells ( CAR-T ) -- The delivery method of the "attack power"
CAR-T CAR-T
"A lot of research in the CAR-T cell field has focused on how to make better cells themselves, but not on how to make cells more efficient in the body," said Eric Appel, co-corresponding author and assistant professor in Stanford's Department of Materials Science and Engineering.
glued together
glued togetherCurrently, intravenous (IV) infusion is the main mode of delivery of CAR-T cells
"It's kind of like a battlefield, full of scary stuff trying to repel these T cells," said Abigail Grosskopf, a doctoral student in chemical engineering and co-first author of the paper
To potently activate CAR-T cells to eradicate tumors, these cells must be chronically exposed to high concentrations of specialized signaling proteins
Instead, Grosskopf and her colleagues developed a hydrogel that can temporarily house cytokines and CAR-T cells near tumors
Injectable hydrogels create a local inflammatory microenvironment for co-delivery of CAR-T cells and cytokines to improve solid tumor therapy
Injectable hydrogels create a local inflammatory microenvironment for co-delivery of CAR-T cells and cytokines to improve solid tumor therapy
"The two components can be injected through a small needle," Grosskopf said.
The hydrogel's meshwork is tight enough to keep tiny cytokines from slipping out
Treat tumors in mice
Treat tumors in miceAfter identifying the optimal hydrogel formulation to deliver cancer treatment, the authors tested it on mice with tumors
The authors also tried injecting hydrogels containing CAR-T cells and cytokines on the opposite side of the mouse body away from the tumor growth
"What we're evaluating is primarily injecting near the tumor," Appel said.
Overall, the new study suggests a simple and effective way to improve a promising cancer treatment
References:
References:1.
1.
Abigail K.
Grosskopf et al.
Delivery of CAR-T cells in a transient injectable stimulatory hydrogel niche improves treatment of solid tumors.
Science Advances, 2022, doi:10.
1126/sciadv.
abn8264.
2.
Simple delivery method enhances a promising cancer treatment
https://medicalxpress.
com/news/2022-04-simple-delivery-method-cancer-treatment.
html
Simple delivery method enhances a promising cancer treatment
https://medicalxpress.
com/news/2022-04-simple-delivery-method-cancer-treatment.
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