-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
| Study reveals the metabolic regulation mechanism of fatty liver developing into liver cancer |
Recently, the research group of Yang Wulin, a researcher from the Institute of Health , Hefei Institute of Material Science , Chinese Academy of Sciences , has made new progress in the field of tumorigenesis and discovered a metabolic regulation mechanism that promotes the malignant transformation of non-alcoholic steatohepatitis
.
The results were published online in the "International Journal of Biological Sciences" a few days ago
Chinese Academy of Sciences
Fatty liver is a common liver pathological change with excessive accumulation of fat in liver cells.
It is the second major liver disease after viral hepatitis
.
Fatty liver disease is generally divided into alcoholic fatty liver and non-alcoholic fatty liver
Starting from the STAM mouse model that mimics the evolution of human fatty liver disease, the research team analyzed the gene expression patterns and gene set variation at each stage of the disease, and found that the extensive activation of carcinogenic signals occurred at the stage of non-alcoholic steatohepatitis, accompanied by regulatory fatty acids.
Specific up-regulation of the metabolic signal axis
.
The synergy of the two will facilitate the occurrence of tumor-initiating cells and promote malignant transformation
This result suggests that the activation of the fatty acid metabolism signal axis is an important factor in the formation and maintenance of liver cancer initiating cells, and targeting this signal axis may provide a potential direction for the prevention of non-alcoholic steatohepatitis-related hepatocellular carcinoma
.
This study also suggests the potential role of lipoprotein lipase LPL molecular inhibitors, such as the weight-loss drug orlistat, in cancer prevention
Related paper information: https://doi.
https://doi.
org/10.
7150/ijbs.
64714 https://doi.
org/10.
7150/ijbs.
64714
