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Although Alzheimer's is one of the most studied diseases due to its high prevalence, the molecular changes that trigger astrocytes (a type of brain cell) to become reactive astrocytes, the current study It is not yet clear that such reactive astrocytes can exhibit a very pronounced morphological change in response to stressful situations in the body, and why neurons in diseased brains have difficulty communicating with each other or with other astrocytes.
Now, in a study titled "Multi-transcriptomic analysis points to early organelle dysfunction in human astrocytes in Alzheimer's disease" published in the international journal Neurobiology of Disease, scientists from Spain analyzed data from nearly 800 deceased individuals.
In the article, the researchers studied the transcriptomic properties of a class of RNA molecules, or cells, that can be used to determine which genes are normally expressed and to what extent.
The findings suggest that there may be a high degree of genetic heterogeneity among individuals with the same clinical diagnosis, and that more than half of the control individuals had molecular features of Alzheimer's disease characterized by neuronal damage and death.
The findings also reveal how, as the disease progresses, astrocytes reduce the expression of genes encoding mitochondrial proteins, thereby preventing mitochondrial dysfunction in these cells
Note: The original text has been deleted
Original source:
Elena Galea, Laura D.
