Study on the protective effect of extract of Polygonum wilfordii on complete cerebral ischemia-reperfusion injury in rats
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Last Update: 2015-04-15
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Source: Internet
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Author: User
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Recently, researchers from the Department of Neurology, Central Hospital of Tujia and Miao Autonomous Prefecture, Enshi, Hubei Province, published a paper to study the protective effect of extract of Polygonum wilfordii on complete cerebral ischemia-reperfusion injury in rats, and preliminarily explore its protective mechanism The results showed that the extract of Nightingale had a protective effect on cerebral ischemia-reperfusion injury, and its protective mechanism was related to the inhibition of no release and the enhancement of scavenging of oxygen free radicals This article was published in the 18th issue of the Journal of clinical and Experimental Medicine in 2014 Wistar rats were randomly divided into two groups: one group was treated with the extract of Nightingale by gavage, the other group was treated with the normal saline by gavage After 72 hours of reperfusion, the blood was cut off and the activity of serum nitric oxide synthetase (NOS), superoxide dismutase (SOD) and the content of nitric oxide (no) and malondialdehyde (MDA) were measured by colorimetry The content of excitatory amino acid (EAA) was measured in ischemic brain tissue Compared with the model group, the activity of serum SOD and the activity of NOS and the content of no and MDA in the rats in the Nightingale group were increased, which could significantly reduce the increase of EAA caused by ischemia and hypoxia, and inhibit the excitatory neurotoxicity caused by EAA.
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