Study analyzes "invasion map" of rice plague bacteria attacking rice immune response

Recently, Professor Zhang Zhengguang of Nanjing Agricultural University published a research paper entitled "A self-balancing circuit centered on MoOsm1 kinase governs adaptive responses to host-derived ROS in Magnarporthe oryzae" in "eLife", which analyzed the rice pestilence bacteria. Protein kinase MoOsm1 phosphate/dephosphate monitoring rice reactive oxygen, control their own pathogenicity, maintain the molecular mechanism of semi-living nutrient growth, thus revealing the rice plague bacteria first "attack the city slightly", and then "war-raising" cunning strategy.
rice pestilence caused by rice pestilence bacteria is the most destructive disease on food crops, threatening food security in China and the world, when serious and even grain-free.
rice pestilence bacteria and rice interoperability early, rice through reactive oxygen bursts,quality accumulation and other immune strategies to suppress the infection of pathogens, and germs secrete a large number of effect proteins into rice to interfere with their immune response.
Although some of the effect proteins and their mechanisms for suppressing the immune response in rice have been reported, how rice pestilence bacteria monitor the immune response in rice, so as to precisely configure the effect proteins to function as a "strategic step" has been a difficult problem for scientists.
The study revealed that rice plague bacteria and rice in the early stages of mutual, rice pestilence bacteria using rice's reactive oxygen induced their own protein kinase MoOsm1 phosphatization levels increased significantly, this phosphatization effect led to the presence of two polymer forms in the cytomegi MoOsm1 disintegation into monomers, into the nucleus.
The kinase enters the nucleus, further phosphorylation transcription factor MoAtf1, prompting it to "escape" the binding of the inhibitor MoTup1, play its transcription activity, induce a large number of redox gene transcription upward expression, inhibit the rice reactive oxygen regulatory immune response.
after this stage of "intense fighting", rice pestilence bacteria have "occupied" the rice immune response of the "city pool", and has controlled the rice "immune soldiers."
However, at this time, the cunning rice pestilence bacteria in order to strengthen themselves, into the "war to support" the second "strategic deployment": to maximize the amount of nutrition from the occupied rice body, to host rice nutrition to strengthen their own strategy.
As a semi-living nutritional fungus, rice pestilence bacteria are initially in the stage of living nutrition, which is settled in the host cell, absorbs the host nutrients to maintain growth without killing the host cells, and then enters the stage of dead nutrition to promote the necrosis of the host cells.
this, in order for the bacteria to continue to draw nutrients from the host through the live nutrition stage, they need to control their own pathogenicity, to avoid premature killing of the host.
so the germs accurately control their own pathogenicity? The study used chromatin immunococipitation (ChIP) technology to identify two protein phosphatase MoPtp1/2 directly regulated by transcription factor MoAtf1.
further studies have found that when rice pestilence bacteria monitor the production of reactive oxygen in rice, the "signal switch" formed by MoOsm1-MoAtf1 activates redox-related genes while also inducing the protein phosphatase coding gene MoPTP1/2 to significantly increase expression.
MoPtp1/2 pairs of protein kinase MoOsm1 dephosphatation, dephosphate MoOsm1 nucleation, turn off its mediated "signal switch", and finally achieve disease-inducing control ... This study expands people's understanding of the monitoring and host immune response of plant pathogenic fungi, helps to understand the pathogenic pathogenicity of pathogens, and is expected to provide reference for the design of efficient and low-toxic rice pestilence control strategies.
()