Studies have revealed that a variety of genes are associated with severe neo-coronary pneumonia

a study of severe cases of neo-crown pneumonia found that some genes make some people more likely to be seriously ill.
the new crown outbreak continues, and there is a question that has been beset by why some people infected with the new crown virus do not have obvious symptoms, while others develop severe symptoms and are even sent to intensive care.
previous studies have found that age and past health conditions, such as obesity, are the main causes of this gap. However, geneticists also want to know if a person's DNA can explain the difference. Now they've found some tantalizing clues.
A British team that has studied more than 2,200 patients with neo-coronary pneumonia has identified common genetic variants associated with severe neo-coronary pneumonia and identified existing drugs that can help treat them, Science reported. Recently, the relevant research was published online on the preprinted platform medRxiv.
"It's really exciting, and every gene provides a potential target for treatment," he said. Priya Duggal, a genetic epidemiologist at Johns Hopkins University in the United States, said.
, an intensive care physician and geneticist at the University of Edinburgh in The United Kingdom, led the new study. "Because of the alarming pace of the new crown pneumonia outbreak, saving even a few months can save many lives." Baillie said.
new study confirmed the involvement of chromosome 3 regions in the new coronary pneumonia process and found a gene called IFNAR2, which encodes cellular subjects of interferon. Interferon is a powerful molecular messenger that activates the immune system when a virus invades a cell. One in four Europeans has a variant of IFNAR2, which increases the risk of severe neocephaly by 30 per cent.
Baillie said the IFNAR2 gene is "completely complementary" to a study published last month in Science: a very rare mutation that causes IFNAR2 and seven other interferon genes to fail could explain about 4 percent of severe cases.
finding of the new study is the OAS gene, which encodes a protein that activates enzymes that break down viral RNA. Any one of these genetic changes could alter the code, which in turn could allow the virus to reproduce. Research data show that this mutation, like the above interferon genetic risk factors, has an impact on the progression of neocyto pneumonia.
team also found other genes that enhance the inflammatory response to lung damage caused by the new coronavirus, which can be fatal in some patients. One is DEP9, which encodes an enzyme known to be associated with lung disease, and TYK2, which encodes a signaling protein associated with inflammation. Drugs for these two gene proteins are already in use, such as DPP9's diabetes enzyme inhibitor and baricitinib (a product of blocking TYK2) for rheumatoid arthritis. (Source: Xu Yue, China Science Journal)
relevant paper information: