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A drug that reduces inflammation and boosts the metabolism of macrophages, immune cells, can reverse cognitive decline in mice, according to a new neuroscience paper published in the internationally renowned academic journal Nature.
the study also suggests some key changes that lead to age-related cognitive decline, and suggests that the symptoms may not be permanent.
inflammation is a key feature of aging and is thought to promote many age-related symptoms such as cognitive decline, neurodegeneration, and atherosclerosis.
the mechanisms that cause and sustain these changes are unclear, the paper's author, Katrin Andreasson of Stanford University School of Medicine in the United States, and colleagues suggest a possible role for macrophages.
aging mice had lower metabolic rates than young mice and had a large number of inflammatory molecules called prosatcin E2 (PGE2).
the authors of the study, cell metabolism returned to younger levels and inflammation was reduced when mice were treated with drugs that inhibited PGE2 signaling path paths.
addition, inhibiting PGE2 signaling paths in mice can reverse age-related memory loss in spatial memory tests and restore the function and plasticity of the mhaima brain region, which is important for learning and memory.
these studies suggest that age-related cognitive decline is not necessarily a static or permanent symptom, and that inhibiting PGE2 signaling path paths can reverse cognitive aging.
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