Studies have found that a lack of an immune protein in the gut can lead to metabolic disorders

Metabolic syndrome refers to the disorder of metabolism of protein, fat, carbohydrate and other substances in human body, and a series of syndromes appear in clinical practice, which is called metabolic syndrome For example, when the glucose metabolism is disordered, the glucose tolerance will decrease, leading to diabetes; when the fat metabolism is disordered, the fatty liver will appear Obesity, high blood viscosity, etc American scientists found that the lack of an immune protein in intestinal epithelial cells can lead to metabolic syndrome and increase the risk of obesity, diabetes and cardiovascular disease The study also found that the regulation of intestinal flora by drugs can help prevent metabolic syndrome Metabolic syndrome is a common pathological state, involving the metabolic disorder of fat, sugar and protein, and other substances Typical symptoms include abdominal obesity, hyperglycemia and hypertension Previous studies have found that TLR4 may be related to this, but the specific mechanism is not clear Researchers from Johns Hopkins Medical Center in the United States recently published a paper in the Journal of mucosal immunology, saying that the experiment found that intestinal epithelial cells lack TLR4 Even if they were fed a high-fat diet, their body weight and body fat increased significantly Moreover, only intestinal epithelial cells lacking this protein can cause metabolic syndrome, while other somatic cells do not Further study found that the lack of TLR4 in intestinal epithelial cells can affect intestinal bacteria, and the use of antibiotics to regulate intestinal flora can prevent metabolic syndrome in experimental rats In addition, the lack of this protein in intestinal epithelial cells also inhibited some of the metabolism genes of mice Therefore, the use of antibiotics to control intestinal flora, or the use of specific substances to activate the body's own metabolic genes, are expected to be used in the prevention and treatment of metabolic syndrome.