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Trimethylamine oxide ( Trimethylamine N-oxide, of TMAO ) is one enteric flora related metabolites derived, was recently found to be a potential risk factor for cardiovascular disease and other chronic diseases , mainly by increasing macrophage cholesterol Accumulation and formation of foam cells, promoting the inflammatory reaction of the arterial wall and increasing the hyperresponsiveness of platelets, etc.
play a role in causing atherosclerosis
.
Not only that, research has also found that TMAO is highly related to diseases such as diabetes, hypertension and even atrial fibrillation
Trimethylamine oxide ( Trimethylamine N-oxide, of TMAO ) is one enteric flora related metabolites derived, was recently found to be a potential risk factor for cardiovascular disease and other chronic diseases , mainly by increasing macrophage cholesterol Accumulation and formation of foam cells, promoting the inflammatory reaction of the arterial wall and increasing the hyperresponsiveness of platelets, etc.
The study included 10756 patients with ischemic stroke/TIA in CNSR-III with baseline TMAO values.
The patients were divided into 4 groups according to their plasma TMAO levels (Q1: <1.
17umol/L; Q2: 1.
17-1.
75umo/L ; Q3: 1.
75-2.
63umol/L; Q4:> 2.
63umol/L)
.
The main outcome of the study was the recurrence of stroke within 1 year of follow-up
The study included 10756 patients with ischemic stroke/TIA in CNSR-III with baseline TMAO values.
As a highly recurring and highly disabling disease, ischemic stroke actively discovers more potential risk factors for stroke recurrence, which is essential for precise treatment and secondary prevention of ischemic stroke based on different etiological classifications
.
This study shows that plasma TMAO is an independent predictor of the risk of stroke recurrence within 1 year, but there are differences in its impact on stroke patients with different TOAST classifications.
As a highly recurring and highly disabling disease, ischemic stroke actively discovers more potential risk factors for stroke recurrence, which is essential for precise treatment and secondary prevention of ischemic stroke based on different etiological classifications
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