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Stroke is the leading cause of death and disability worldwide, with an estimated 5.
5 million deaths in 2016
.
Developing countries account for more than two-thirds of the stroke burden
Stroke affects female and male patients differently, but the source and consequences of these differences are unclear
.
Some evidence suggests that female patients have lower in-hospital mortality and more favorable functional outcomes
Previous studies on gender differences have primarily measured stroke outcomes at discharge or in the first few months after stroke onset
.
Still other studies were conducted in a single center, or in small, unrepresentative registries, or did not include potential confounders, leading to controversial gender-related results
With this, Meng Wang et al.
, of Beijing Tiantan Hospital, explored gender differences in stroke outcomes, including stroke recurrence, mortality, and functional outcomes at 3, 6, and 12 months after stroke, a large multi-disciplinary study.
Central Stroke Registry Study, involving hospitals across China
.
Of the 15,166 patients registered between 2015 and 2018, 9,038 patients with acute ischemic stroke (AIS) were included
.
The primary outcomes were stroke recurrence, mortality, and adverse functional outcomes (modified Rankin Scale [mRS] > 2) at 3, 6, and 12 months
Cox regression models were used for stroke recurrence and mortality, and logistic regression models were used for adverse functional outcomes, with the following adjustments
.
(1) Model 1: no adjustment;
(2) Model 2: Adjustment for underlying risk factors, NIHSS on admission, pre-stroke mRS, tissue plasminogen activator (TPA) treatment, TOAST classification, and onset-admission time;
(3) Model 3: In addition to blood pressure and serum covariates, the covariates of Model 2 were adjusted
.
Multiple attribution was used for missing values, and sensitivity analyses were performed to describe sex differences across age groups
They found: One third of the patients (2802/9038) were women
.
Women were significantly older than men (64.
78±10.
The significance of the study lies in its findings: Compared with men, women with AIS in China are less likely to have a favorable outcome within 3 months , especially in people over 65 years of age
.
Experts should aim to tailor secondary prevention strategies for high-risk patients
Compared with men, women with AIS are less likely to have favorable outcomes within 3 months in China
Original source:
Wang M, Wang C, Gu HQ, et al.
Sex Differences in Short-term and Long-term Outcomes among Acute Ischemic Stroke Patients in China.
Stroke.
Published online February 8, 2022:STROKEAHA.
121.
037121.
doi:10.
1161 /STROKEAHA.
121.
037121leave a message here
