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Compared with single antiplatelet therapy (SAPT), dual antiplatelet therapy (DAPT) after ischemic stroke or transient ischemic attack may reduce recurrent strokes, but it also increases the chance of severe bleeding.
Stroke
Recently, the medsci.
medsci.
Researchers searched the Medline, Embase, and Cochrane databases on December 5, 2019 to identify phase III or IV randomized controlled trials (n≥100) published between December 1999 and December 2019.
Short-term test forest map
The researchers identified three short-term short-term randomized controlled trials that mainly recruited patients with mild stroke or high-risk transient ischemic attack.
Long-term test forest map
In 2 randomized controlled trials of long-term treatment (average treatment time of 18-40 months), DAPT was not correlated with a significant reduction in recurrent ischemic stroke (combined RR was 0.
It can be seen that DAPT is more effective than SAPT in preventing secondary ischemic stroke when anticoagulation therapy is started after a mild stroke/high-risk transient ischemic attack and the duration is less than 90 days .
DAPT is more effective than SAPT in preventing secondary ischemic stroke when anticoagulation therapy is started after a mild stroke/high-risk transient ischemic attack and the duration is <90 days
Original source:
Original source:Devin L.
Benefits and Risks of Dual Versus Single Antiplatelet Therapy for Secondary Stroke Prevention: A Systematic Review for the 2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack
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