Stroke: Stroke, aspirin treatment fails, what anti-thrombotic programs are there?

In the United States, more than 40% of adults over the age of 70 take aspirin heart blood vessels of primary disease prevention , more than 70% of any age with a history of cardiovascular disease, daily aspirin
.

Although aspirin is often used for the prevention of cardiovascular disease and stroke, many patients taking aspirin monotherapy still suffer from ischemic stroke (so-called aspirin failure)
.

In this way, Jay B.
Lusk and others of the University of Texas Southwestern Medical Center evaluated the incidence of aspirin failure in elderly patients with acute ischemic stroke and described the antithrombotic treatment for secondary stroke prevention when they were discharged from the hospital.
Prescription model
.

They used data from the American Heart Association’s Get With The Guidelines Stroke Registry to describe the discharge antithrombotic treatment model of ischemic stroke beneficiaries from 1734 hospitals in the United States from October 2012 to December 2017.
These beneficiaries were in He took aspirin before the stroke and was discharged alive
.

Among the 261 survivors of ischemic stroke, 100,016 (38.
2%) took aspirin monotherapy before stroke
.

The next most common treatment option is dual antiplatelet therapy (24.
6%), followed by clopidogrel monotherapy (17.
8%)
.

The remaining 13.
2% of patients were discharged with aspirin/dipyridamole, warfarin or non-vitamin K antagonist oral anticoagulants, with or without antiplatelet therapy, or no antithrombotic therapy at all
.

The significance of this study lies in the discovery that among the patients with ischemic stroke who received aspirin preventive treatment, nearly half of the patients received aspirin monotherapy after discharge without changing antithrombotic drugs, while the other half of the patients received clopidogrel after discharge.
Single-agent therapy, dual antiplatelet therapy or other less commonly used drugs
.

These findings emphasize the need for future research to determine the best management strategy for this very common and complex clinical situation
.

Original source:
Lusk JB, Xu H, Peterson ED, et al.