Stroke: Relationship between the severity of non-alcoholic fatty liver disease and the risk of ischemic stroke

In a recent study published in TheStroke, an authoritative journal in the field of cardiovascular disease, researchers aim to proactively assess whether non-alcoholic fatty liver disease (NAFLD) and its severity can predict the occurrence of community-based ischemic stroke (IS).
excluding alcoholism and other liver diseases, the researchers recruited participants with no history of stroke, cancer, or myocardial infarction.
to evaluate NAFLD through an ultrasound.
NAFLD participants were further divided into mild, moderate and severe.
ended with the first appearance of IS.
secondary outcomes include myocardial infarction and combined vascular events.
researchers adjusted factors such as age, gender, physical activity, body mass index, smokers, history of hypertension, diabetes, hypercholesterolemia, lipid levels, lipid-lowering drugs, high-density lipoprotein (HDL), triglycerides, hypersensitive C-reactive protein (hsCRP), and an empty stomach blood sugar, and used Cox-scale risk models to estimate the risk ratio and 95% CI of IS events based on NAFLD levels and severity.
3,490 strokes from 79,905 participants over an average of 10.34 years of follow-up.
found NAFLD among 24,874 (31.18%) participants.
participants who did not have NAFLD at baseline were adjusted for mixed variables, the risk of IS occurring in NAFLD patients increased by 16% (95% CI was 1.07-1.26).
risk ratios were 1.15 (95% CI 1.05-1.25), 1.19 (95% CI 1.06-1.34) and 1.21 (95% CI 1.08-1.50), respectively.
, the severity of NAFLD is associated with a higher risk of future IS events.
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