 Home > Active Ingredient News > Study of Nervous System > Stroke: New discoveries in the field: 14-year follow-up of small vessel disease, what is the dynamic change process?

Stroke: New discoveries in the field: 14-year follow-up of small vessel disease, what is the dynamic change process?

 Last Update: 2022-08-12
 Source: Internet
 Author: User

Tags

color dynamics

recipes 1 year old

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

Cerebral small vessel disease (SVD) is the most important vascular factor leading to dementia, accounting for one-fifth of all strokes worldwi.

Figure 1: Paper cover image

The development of these lesions is associated with adverse functional outcomes, including cognitive decline, gait dysfunction, and depressi.

New evidence shows that some patients with SVD have a reduction in lesio.

Therefore, studies with longer follow-up and serial follow-up MRI scans are needed to fully investigate the temporal dynamics of SVD and its determinan.

In this way, Mengfei Cai (Cai Mengfei) and Mina Jacob of the Nijmegen University Medical Center in the Netherlands, and others, used the RUN DMC small vessel disease cohort (Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort) established by Pr.

The RUNDMC cohort, enrolled 503 sporadic SVD patients (50-85 years old) in 2006 with baseline assessment and follow-up in 2011, 2015, and 202 Vascular risk factors and magnetic resonance imaging markers of SVD were assess.

In this study, a total of 382 patients with SVD (mean [SD] 61 [4]; 219 men and 163 women) who underwent at least 2 consecutive brain MRI scans with a mean (SD) follow-up of 115 ( 32) yea.

They found that the time course of SVD is highly variab.

Figure 2 The results of the paper

About 4% of patients experienced WMH net regression within 14 years, while 38 of 361 patients (15%), 5 of 296 patients (2%), and 61 of 231 patients (26%) WMH regressions appeared during 2006-2011, 2011-2015, and 2015-2020, respective.

Of these, 29 (76%), 5 (100%) and 57 (93%) showed overall progression at 14 years of follow-up, taking into account all participants, the net WMH between the first and last scans The overall change is the net average progress in WMH over a 14-year peri.

Figure 3: Abstract of the paper image

Older age was a strong predictor of faster WMH progression and the onset of lacu.

Furthermore, both baseline SVD lesion burden and vascular risk factors independently and synergistically predicted WMH progression, whereas only baseline SVD burden predicted new-onset lacune at 14 years of follow-.

The significance of this study lies in its findings: SVD shows marked progression over time, but mild WMH rarely develops clinically severe WM.

WMH regression is notable during some MRI intervals, although it may be generally compensated for by progression at long-term follow-.

SVD shows marked progression over time, but mild WMH rarely progresses to clinically severe WMH

Original source:Cai M, Jacob MA, van Loenen MR, et .

Determinants and Temporal Dynamics of Cerebral Small Vessel Disease: 14-Year Follow-.

_Stroke.

Published online May 4, 2022:11161/STROKEA.

1203809 doi: [11161/STROKEA.

12038099](https://d.

org/11161/STROKEA.

12038099)

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.