-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Kawasaki disease (KD) was first reported by a Japanese pediatrician in 1967.
It is a common type of vasculitis of unknown cause that usually occurs in infancy and childhood
.
Children with KD may have severe cardiovascular sequelae, especially coronary artery abnormalities, which may lead to myocardial ischemia, infarction and sudden death
In 2006, the American Heart Association listed KD as a high-risk pediatric disease that can cause clinical cardiovascular events in affected children and adults early in life
.
The American Academy of Pediatrics also recognizes this and emphasizes the importance of reducing cardiovascular risk in children with KD
Cerebrovascular disease (CVD) may be one of the complications of KD; however, since KD itself was first confirmed in 1967, few studies in the literature report the risk of subsequent CVD in children with KD
.
Therefore, even the oldest known KD patients are only middle-aged, so there is not enough follow-up time to capture enough events
In addition, although there have been some studies investigating CVD after KD in the past few decades, their reported conclusions are not consistent.
In this way, Chien-Heng Lin and others from Taiwan, China hypothesized that children with KD may have an increased risk of subsequent CVD compared with healthy children
.
They collected KD children (0-18 years old) data (n=8467) from the National Health Insurance Research Database in Taiwan
.
From the first year of observation (called the baseline year), collect data on each child with KD, and randomly select 4 non-KD patients with matching gender, urbanization level of residence, and parental occupation to form a non-KD cohort ( n=33 868) for analysis
They found that the overall incidence of cerebrovascular disease in the KD cohort was 3.
19 times higher than that in the non-KD cohort (14.
73 vs.
In addition, in the KD cohort, children younger than 5 years of age have a significantly higher risk of subsequent cerebrovascular disease (adjusted hazard ratio, 3.
The significance of this study lies in the discovery: This nationwide retrospective cohort study showed that KD may increase the risk of subsequent cerebrovascular diseases , especially those with KD younger than 5 years old
This nationwide retrospective cohort study shows that KD may increase the risk of subsequent cerebrovascular diseases
Original source:
Lin CH, Lai JN, Lee IC, et al.
Leave a message here
