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The incidence of unruptured intracranial aneurysms (UIAs) is 3%
.
At the time of rupture, ≈50% of patients will die, and 50% of surviving patients will have serious complications
The gut microbiota is an environmental factor that contributes to human pathophysiology and is involved in various diseases, in which inflammation plays a key role in determining the course and severity of the disease
.
Intestinal microbial group and cardiac vascular relationship between the diseases (e.
Blood vessel
In CAs, an animal model study showed that the consumption of antibiotics on the gut microbiome promotes the pathophysiology of the aneurysm wall through inflammation regulation
.
Hungatella hathewayi microorganisms are also involved in the occurrence of UIA
antibiotic
In this way, Shuhei Kawabata et al.
hypothesized that there are differences in the types of microbiome profiles between stable UIA patients and unstable UIA patients that eventually rupture.
This difference may lead to chronic inflammation and pathophysiological changes in the aneurysm wall, and ultimately lead to aneurysms.
Rupture (RAs)
.
To explore the relationship between RAs and the microbiome, they compared the gut microbiome of UIAs and RAs patients immediately after the onset of the disease, and identified the bacteria that cause RAs
.
From 2019 to 2020, a one-year multi-center, prospective case-control study was conducted
.
Stool samples taken immediately after the onset of stable UIAs and RAs patients
A total of 28 RAs and 33 UIAs were included in this study
.
There were no differences in patient characteristics between RAs and UIAs: age, gender, hypertension , dyslipidemia, diabetes status, body mass index, and smoking
Hypertension diabetes
At the phylum level, the relative abundance of Campylobacter in the RA group was greater than that in the UIA group
.
In addition, the gut microbiome of the RA group and the UIA group showed significantly different classifications
The relative abundance of Campylobacter in RA group was greater than that in UIA group
Then, a phylogenetic tree of operational taxa related to Campylobacter was constructed, and 4 species were identified
.
By polymerase chain reaction of these species, it was found that the abundance of Campylobacter and Campylobacter uremicus was significantly higher in the RA group
The important significance of this study lies in the discovery: the intestinal microbiome profiles of patients with stable UIAs and RAs are significantly different
.
Campylobacter and Urolytic Campylobacter may be related to the rupture of cerebral aneurysm
.
The gut microbiome profiles of patients with stable UIAs and RAs are significantly different
.
Campylobacter and Urolytic Campylobacter may be related to the rupture of cerebral aneurysm
.
Original source:
Kawabata S, Takagaki M, Nakamura H, et al.
Dysbiosis of Gut Microbiome Is Associated With Rupture of Cerebral Aneurysms.
Stroke.
Published online November 3, 2021:STROKEAHA.
121.
034792.
doi:10.
1161/STROKEAHA.
121.
034792
Stroke.
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