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Stroke is one of the leading causes of death worldwide
.
According to the Global Burden of Disease Study, there were nearly 80.
Current stroke prevention guidelines identify risk factors such as high blood pressure , diabetes , heart rhythm disorders, hyperlipidemia and other lipids
.
However, these only partially explain the difference in stroke risk between women and men
Prevention Guidelines for Hypertension Diabetes
Pregnancy and childbirth are special stages in a woman's life
.
A growing body of research suggests that pregnancy complications and pregnancy outcomes, such as having gestational hypertension, gestational diabetes and preeclampsia, preterm birth, and babies of small gestational age, are associated with long-term risk of stroke or cerebrovascular
Blood vessel
However, only limited studies have explored the association with infertility, miscarriage and stillbirth, which are common abnormalities during conception and pregnancy
.
Infertility, miscarriage, stillbirth, and stroke share some common risk factors, such as unstable diabetes, hypertensive disease, obesity, and smoking
To date, four meta-analyses have pooled findings on infertility, miscarriage, stillbirth, and stroke
.
However, as of 2014, each review included no more than four studies
A comprehensive literature search was performed for cohort and case-control studies of the association between infertility, miscarriage, stillbirth, and stroke as of September 26, 2020
.
Seven databases were searched
This meta-analysis was conducted from 16 cohort studies and 2 case-control studies including a total of 7 808 521 women
.
Women who experienced a miscarriage or stillbirth had a higher risk of stroke (miscarriage: HR, 1.
07 [95% CI, 1.
In subgroup analyses, increased risk of stroke was associated with recurrent miscarriage and stillbirth (≥3 miscarriages: HR, 1.
42 [95% CI, 1.
05-1.
90]; ≥2 stillbirths: HR, 1.
14 [95% CI, 1.
04-] 1.
26])
.
The association between infertility and stroke was inconsistent and inconclusive (HR, 1.
07 [95% CI, 0.
87-1.
32])
.
Increased risk of stroke linked to recurrent miscarriages and stillbirths
The significance of the study is that it found that miscarriage and stillbirth were associated with an increased risk of stroke in women, which could be used as a risk factor to help identify women at higher risk for stroke
.
.
Original source:
Liang C, Chung HF, Dobson AJ, Mishra GD.
Infertility, Miscarriage, Stillbirth, and the Risk of Stroke Among Women: A Systematic Review and Meta-Analysis.
Stroke .
Published online January 5, 2022:STROKEAHA.
121.
036271.
doi: 10.
1161/STROKEAHA.
121.
036271
Infertility, Miscarriage, Stillbirth, and the Risk of Stroke Among Women: A Systematic Review and Meta-Analysis.
Stroke
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