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HDL (High Density Lipoprotein) cholesterol levels are closely related to the risk of coronary heart disease (CHD) and are inversely proportional
.
In contrast, studies on plasma high-density lipoprotein cholesterol and clinically defined stroke risk usually find a weak association with coronary heart disease, and the results of the study are also inconsistent
cholesterol
In 2004 CHS ( heart blood vessel health research) report, a higher high-density lipoprotein cholesterol and the risk of ischemic stroke in men less about, but nothing to do with women
.
Occult cerebral infarction, that is, a lesion detected on brain imaging without clinically recognized stroke symptoms, is very common in the elderly
Heart blood vessels that stroke or participants no obvious clinical definition of transient cerebral ischemic attack, the results are mixed
If apoC3 is present on HDL, HDL may not exert an anti-inflammatory effect
.
Although the inverse ratio of HDL without apoC3 to CHD risk is even stronger than that of total HDL, the association between HDL with apoC3 and CHD risk is much weaker than that of total HDL
Higher plasma apoE was previously associated with a higher risk of ischemic stroke, so the relationship between HDL and apoE and vascular brain injury may be weaker than that of total HDL
.
Conversely, higher plasma apoJ is associated with a lower risk of stroke, so the association between HDL and apoJ may be stronger than that of total HDL
To address the role of apo transport between the HDL and vascular brain injury, Harvard University Manja Koch et al.
, Studied the incidence of subspecies and subtle cerebral infarction HDL and apo-defined and publicly ischemic brain occurs stroke of The association of risks
In cross-sectional analysis, participants with higher apoA1 in plasma and lower apoE in HDL were less likely to have infarcts defined by the popular covert MRI: the odds ratio of apoA1 Q4 to Q1 was 0.
68 (95% CI, 0.
50 -0.
93), the odds ratio of apoE Q4 to Q1 is 1.
36 (95% CI, 1.
Similarly, in prospective analysis, apoA1 in HDL subspecies lacking apoC3, apoJ or apoE was inversely proportional to occult infarction, while apoE in HDL subspecies lacking apoC3 or apoJ was directly related to occult infarction
.
In contrast, the concentration of supplemental HDL subspecies containing these apoA1 and apoE is not associated with occult infarction
.
The pattern of association between the occurrence of obvious ischemic stroke and apoA1, apoE, and apoA1 and apoE in the HDL subspecies is similar to the observed recessive infarction, but is less obvious
.
This study emphasizes that the HDL subspecies defined by apo content is a relevant biomarker of concealed and symptomatic vascular brain damage
.
.
Original Source:
Koch M, Aroner SA, Fitzpatrick AL, et al.
HDL (High-Density Lipoprotein) Subspecies, Prevalent Covert Brain Infarcts, and Incident Overt Ischemic Stroke: Cardiovascular Health Study.
Stroke.
Published online October 14, 2021: STROKEAHA.
121.
034299.
doi:10.
1161/STROKEAHA.
121.
034299
