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Hemorrhagic transformation (HT) refers to intracerebral hemorrhage that occurs when blood vessels restore blood perfusion after acute ischemic stroke , and is one of the common complications of ischemic stroke .
HT includes spontaneous bleeding and bleeding after treatment.
The incidence varies depending on the study selection criteria, ranging from 0.
Hemorrhagic transformation (HT) refers to intracerebral hemorrhage that occurs when blood vessels restore blood perfusion after acute ischemic stroke , and is one of the common complications of ischemic stroke .
thrombus
In order to evaluate the clinical and imaging characteristics related to HT, sICH and parenchymal hematoma (PH) in patients with acute ischemic stroke after EVT with and without intravenous alteplase, Liu Jianmin from the Department of Neurosurgery of Shanghai Changhai Hospital insisted on the team.
The analysis was carried out in the DIRECT-MT trial and the results were published in the journal Stroke
The DIRECT-MT trial is a randomized trial of EVT alone and intravenous thrombolysis combined with EVT
.
Follow-up computed tomography scans evaluated HT, sICH, and PH
Results A total of 633 patients were analyzed; 261 (41.
2%) had HT; 34 (5.
4%) had sICH; 85 (13.
4%) had PH
.
The median age is 69 years and 56.
In general, symptomatic intracranial hemorrhage is associated with higher NIHSS scores (OR=1.
06; 95% CI, 1.
10-1.
12) and higher glucose levels on admission (OR=1.
14; 95% CI, 1.
00-1.
29) Related
.
However, no relationship was found between alteplase treatment and HT, sICH or PH
Symptomatic intracranial hemorrhage is associated with higher NIHSS scores (OR=1.
The independent predictors of sICH were the higher baseline NIHSS score (OR=1.
In summary, in DIRECT-MT, the independent predictors of sICH are the baseline NIHSS score and the glucose level at admission
.
Alteplase treatment did not increase the risk of HT, sICH or PH after EVT
In summary, in DIRECT-MT, the independent predictors of sICH are the baseline NIHSS score and the glucose level at admission
references:
Clinical and Imaging Indicators of Hemorrhagic Transformation in Acute Ischemic Stroke After Endovascular Thrombectomy.
Stroke.
2021;0:STROKEAHA.
121.
035425.
Https://doi.
org/10.
1161/STROKEAHA.
121.
035425 .
Https://doi.
org/10.
1161/STROKEAHA.
121.
035425 Leave a message here
