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Observational studies have demonstrated an association between stroke and cardiac characteristics , with the exception of atrial fibrillation (a major source of cardioembolism)
.
However, the causal role of these features in stroke pathogenesis remains controversial
stroke
In this study, researchers systematically assessed the association between cardiac characteristics and stroke risk through a Mendelian randomization framework using genetic data
.
The researchers explored the characteristics of 66 cardiac findings, including cardiovascular disease, magnetic resonance imaging-derived cardiac imaging, echocardiographic imaging, and electrocardiographic indicators, as well as blood biomarkers in a 2-sample Mendelian randomization approach
.
In data from the MEGASTROKE consortium (40,585 cases/406,111 controls), researchers explored the association between genetic susceptibility for each trait and stroke risk and stroke subtype
As expected, the researchers observed strong independent associations between atrial fibrillation and genetic susceptibility to cardioembolic stroke, as well as genetic susceptibility to coronary artery disease (as a proxy for atherosclerosis and large-artery stroke)
.
The study's data-driven analysis further showed an association between genetic predisposition and heart failure and low resting heart rate and stroke
CONCLUSIONS: The available genetic data do not support a substantial effect of cardiac characteristics on stroke risk beyond known clinical risk factors
.
The findings of this study underscore the need to carefully control for confounding and other potential biases in studies evaluating candidate cardiac risk factors for stroke
Available genetic data do not support a substantial effect of cardiac characteristics on stroke risk beyond known clinical risk factors
Original source:
Simon Frerich.
