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Ischemic stroke and transient ischemic attack are the most common cerebrovascular complications after heart transplantation (HT)
Vascular Immunity
Recently, it has been shown that switching to sirolimus is associated with a significant decrease in the progression of vascular disease in heart transplantation when CNI treatment is completely stopped
In view of the effect of sirolimus on the vascular bed, the effect of sirolimus on the risk of stroke may be mediated by reducing the stenosis of extracardiac blood vessels in the brain, and there is no research yet
In this way, Hilmi Alnsasra and others of the Mayo Clinic explored whether immunosuppression from CNI to sirolimus is related to the decrease in the incidence of stroke, and evaluated the incidence, risk factors and prognostic significance of stroke in the HT population
They retrospectively analyzed the incidence of ischemic and hemorrhagic strokes and related results in all consecutive HT recipients transplanted in an institution from 1994 to 2016
Of the 529 patients who received HT, 57 (10.
They found that age at HT (adjusted hazard ratio [HR]1.
diabetes
Patients with stroke (any type) are more likely to have worse renal function (HR, 1.
Stroke
Cytomegalovirus infection is associated with an increased risk of any stroke (HR, 2.
Infection with calcineurin inhibitors compared maintenance therapy, the calcineurin inhibitor is converted to significant changes in immunosuppression and risk of stroke based on independent sirolimus (the HR, 1.
The significance of this study lies in the discovery: Stroke after HT is related to an increase in mortality
Stroke after HT is associated with an increase in mortality
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