Strengthening the effect of the mutant strain is remarkable, and the fourth dose of the vaccine is conducive to improving the protective effect of the elderly New crown research progress in one week

People who have been infected with the new coronavirus and have been vaccinated have the strongest resistance to the mutant strain

Source: the Lancet Infectious Diseases

A recent study published in the Lancet Infectious Diseases shows that people who have been infected with the new coronavirus and have been vaccinated gain the strongest resistance to the new coronavirus variant

Researchers collected health data from more than 200,000 Brazilians from 2020-2021 and found that the Pfizer and AstraZeneca vaccines were more effective at preventing hospitalizations and deaths in people who had been infected with the new coronavirus than in people who had not been infected.

Easing controls will lead to a sharp rebound in coronavirus deaths in the short term

Source: JAMA Health Forum

On April 1, a study published in the JAMA Health Forum showed that while maintaining the current pace of vaccination, easing restrictions would lead to a sharp rebound in COVID-19-related deaths in the short term

The research team conducted a simulation study to predict changes in the mortality rate of Covid-19 after the relaxation of mask requirements and social distancing restrictions at different time points

Potential brain damage may occur after COVID-19 infection

Source: Nature Communications

A study published in Nature Communications on April 1 used a non-human primate model infected with the new coronavirus to show in detail how the new coronavirus affects the nervous system

The research experimental group included 8 adult monkeys, including 4 rhesus monkeys and 4 African green monkeys, who were infected with the original strain of the new coronavirus through multi-channel mucosal inoculation or aerosol atomization

However, the editor of Mays reminds: This is only an animal study and does not represent the actual role of the human body

Immune evasion of Omicron mixed subtype XD revealed

Source: Research Square

On April 4, a study published on the preprint platform Research Square reported on the virological signature of XD, the Delta-Omicron recombinant subtype

The study showed that the immune escape of this strain is characterized by Omicron BA.

Differential transcriptional maps of multiple organs in rhesus monkeys infected with 2019-nCoV are mapped

Source: Protein & Cell

On April 4, a work published in "Protein & Cell" (Protein & Cell), the research team found that the new coronavirus has extensive distribution and replication in various tissues and organs, and drew a map of differential transcriptional changes in various tissues and organs.

The researchers first collected and extracted multiple organs and tissues from healthy control rhesus monkeys and rhesus monkeys 7 days after infection with the new coronavirus, conducted RNAscope and digital PCR experiments, and found that the new coronavirus has extensive replication and transcription in various tissues and organs.

Strengthening the effect of new crown variant strains is remarkable

Source: Science Translational Medicine

On April 5, a study published in "Science Translational Medicine" revealed the neutralizing effect of serum after vaccine booster vaccination on Omicron through clinical trials, indicating the potential protection of booster needles force

After the researchers tested the sera of 39 healthy health care workers for neutralizing antibodies against the virus, they found that only 7.

The fourth dose of the vaccine is beneficial to improve the protection effect of the elderly

Source: NEJM

On April 5, a study published in the "New England Journal of Medicine" (NEJM) showed that the fourth dose of the new crown vaccine can improve the protection effect of severe disease by about 2.

The study selected the health data of more than 1 million elderly people during the period when the Omicron variant was the main strain to evaluate the effectiveness of the fourth vaccine for the elderly

Novel coronavirus main protease recognizes substrates and catalyzes reactions reported systematically

Source: PNAS

On April 5, a study published in the "Proceedings of the National Academy of Sciences" (PNAS) reported that the key drug target of the new coronavirus, the main protease, has high levels in the resting state, the intermediate state of binding to the substrate, and the post-cleavage state.

The research team solved the high-resolution complex structure of the main protease mutant and the polypeptide substrate at 6 sites, respectively
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Through analysis, it was found that the main protease of 2019-nCoV can recognize substrates with a length of 10 amino acid residues, but it is only selective for 4 sites of S1, S2, S4 and S1'
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This study is the first to systematically report the substrate recognition specificity and catalytic mechanism of the main protease of 2019-nCoV, which lays an important structural foundation for the design of more efficient anti-2019-nCoV drugs
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Covid-19 antibody treatment may exacerbate inflammation

Source: Nature

On April 6, a study published in "Nature" revealed for the first time the mechanism of severe inflammation, acute respiratory distress and multiple organ damage caused by new crown infection
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The study found that the new coronavirus can infect monocytes and macrophages.
Once infected, these cells will rapidly die due to pyroptosis before the new virus is fully formed, thereby releasing a powerful inflammatory alarm signal
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The researchers believe that antibody treatment against the new crown spike protein may exacerbate the inflammatory response, which explains why antibody treatment is only effective when given early in the infection
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Targeting alveolar macrophages is an effective strategy for early control of 2019-nCoV infection

Source: Signal Transduction and Targeted Therapy

On April 6, a study published in "Signal Transduction and Targeted Therapy" found that targeting alveolar macrophages is an effective strategy for early control of new coronavirus infection, and through new coronary pneumonia.
The mouse model found two old drugs commonly used in clinical practice
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The research team found that bisphosphonates such as alendronate (ALN) and the glucocorticoid drug dexamethasone (Dex) can synergistically block the expression of a proteolytic enzyme CTSL and endosome pH, respectively.
Viruses escape from endosomes
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The effect of this combination therapy must be achieved through the topical route of nasal spray, and it can exert the anti-inflammatory effect of hormones
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This spray therapy is simple, safe, low-cost, and easy to popularize and use.
It is a new strategy for early control of 2019-nCoV infection worthy of further in-depth study
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High levels of ACE2 in plasma linked to increased rates of new coronavirus infection

Source: Circulation

On April 7, a study published in Circulation showed that elevated ACE2 levels were positively associated with COVID-19 severity, hospitalization, and infection
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The study conducted a genome-wide association meta-analysis of plasma ACE2 levels in more than 28,000 individuals, summarized the cross-sectional epidemiological correlation of circulating ACE2, and identified 10 loci, including 8 novel loci, that captured 30% of Protein heritability
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Plasma ACE2 was detected to be genetically associated with vascular disease, severe COVID-19, and a wide range of complex human diseases
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In addition, Mendelian randomization analysis based on X chromosome cis-pQTL showed that elevated ACE2 levels were positively associated with COVID-19 severity, hospitalization, and infection
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