Stem cells dev: a new regulator of bone formation

March 14, 2019 / BIOON / - researchers found that a new transcription factor in mice can help regulate the differentiation of mesenchymal stem cells (MSCs) into bone At present, the research of bone cell differentiation is not in-depth, and MSCs is a potential source of stem cells in the field of regenerative medicine Photo source: stem cells and development, a new transcription factor, is called osteoblast inducer 1 (obi-1) Relevant research results were recently published in stem cells and development This paper is called "Identification of a Novel Transcription Factor Required for Osteogenic Differentiation of Mesenchymal Stem Cells." the authors include Francesca Querques and Anna dagostino from the University of Naples, Italy, Federico II, and their colleagues, as well as a group of scientists from the CRG gene regulatory center in Spain The researchers found that obl-1 when they screened MSCs, and then they carried out in-depth research, and found that this factor played a role by stimulating BMP signal pathway to control the expression of Runx2 to some extent "Lucio Pastore and his colleagues have reported for the first time a new transcription factor they call osteoblast inducible factor 1, which can control bone differentiation by controlling signals upstream of Runx2 In their paper, they validated these results with gene knockout and overexpression experiments on pluripotent mouse bone marrow cells and primary mouse mesenchymal stem cells " Said Graham C Parker, PhD, editor in chief of the journal and at Wayne State University School of medicine Reference: Francesca querques et al, identification of a new transcription factor required for osteogenic differentiation of mesenchymal stem cells, stem cells and development (2019) Doi: 10.1089/scd.2018.0152