Stem Cell Reports: Men are more likely to develop colorectal cancer, which is associated with androgen levels.

According to the latest statistics of the World Health Organization (WHO), colorectal cancer is the third most common cancer in the world and the second most fatal.
Colorectal cancer can occur at any age, but mostly only affects the elderly, and it usually begins with small, benign cell clusters called veals formed inside the colon, but over time, some of these veals may become cancerous.
in the United States and some other developed countries, the incidence of colorectal cancer has stabilized or is declining, but in some developing countries, particularly in China, the incidence and mortality of colorectal cancer is increasing.
Although we have made great progress in surgical techniques and treatment of colorectal cancer, the five-year relative survival rate of colorectal cancer patients has not improved significantly over the past few decades.
, there is an urgent need to better understand the molecular mechanisms that regulate the occurrence and development of colorectal cancer.
, studies have shown that men have a higher incidence of colorectal cancer and that men with colorectal cancer have significantly higher mortality rates than women.
, the molecular mechanism of this gender difference is still unknown.
recently, Li Jingxin of The Qilu School of Medicine at Shandong University and others published a research paper entitled Androgen Maintenances Intestinal Homeostasis by Inspire BMP Signaling via Intestinal Stromal Cells in stem Cell Reports.
the study revealed the role of male hormones in the proliferation and differentiation of intestinal stem cells by targeting male hormones in intestinal substrate cells and negatively regulating the path of BMP preferences.
study provides a possible explanation for the high incidence of colorectal cancer in men.
, the study laid the groundwork for the treatment of colorectal cancer by regulating male hormones.
many lifestyle-related factors are associated with colorectal cancer, and the link between diet, weight and exercise and colorectal cancer risk is more closely linked than other types of cancer.
and colorectal cancer is strongly influenced by sex, and morbidity and mortality rates are significantly higher in men than in women.
has previously shown that the arrangement between the intestine and colon foreskin is similar to the micro-environment of stem cells, and by regulating androgen levels in mice, the team found that asosteroid levels cause intestinal stem cells (ISCs) to divide more than usual and produce fewer mature endocrine cells.
, the team performed testosterone removal, ovary removal, and inhibition of androgens in male mice to study the effects of androgens on end-of-intestinal stem cell (ISC) differentiation.
results showed that male cup cells, intestinal endocrine cells and Paneth cells increased after testosterone, compared to the control group, and that the addition of testosterone (DHT) reversed this phenomenon.
also found that androgens may reduce the number of secreted genealogy and intestinal cortectal cells.
Then, the researchers selectively inhibited the BMP path, which was consistent with the reverse effect of exogenous androgens, and BMP inhibitors reversed the increase in the secretion lineage and cell proliferation caused by testicular excision.
researchers also suppressed an increase in BMP downstream signals (Id1 and Msx1), further demonstrating that androgens may be the selective inhibitors of the BMP path.
, androgen-like exciters inhibit intestinal stem cell (ISC) differentiation, but increase cell proliferation in mice with ovarian removal.
the mechanism, the activation of androgen receptors increases the expression of BMP inhibitors in primary substation cells, but reduces the expression of BMP4 and Wnt inhibitors, thereby promoting the growth of intestinal organs.
overall, the study sheds light on the role of male hormones in promoting proliferation and inhibiting differentiation, suggesting that substrate cells form the microenvironment of intestinal stem cells and providing a possible explanation for the high incidence of colorectal cancer in men.
, the study laid the groundwork for the treatment of colorectal cancer by regulating male hormones.
.