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September 14, 2020 // -- In a recent study published in the international journal Stem Cell Reports entitled "Androgen Maintenances Intestinal Homeostasis by Andring BMP Signaling via Intestinal Stromal Cells", scientists from Shandong University in China and other institutions found that stem cell function may help explain why colon cancer is more common in the male population.
Photo Source: truthinsideofyou.org We all know that colon cancer has a higher incidence in men, which may be related in part to higher levels of male body androgens than women, but the exact cause is not yet clear to researchers; in this study, researchers found a mysterious link between androgens and stem cells that promote colon cancer, some of which are often thought to originate from intestinal endostrophic stem cells, which are necessary for normal tissue maintenance and regeneration in the body.
researcher Dr. Jingxin Li said androgen levels regulate the regeneration of intestinal endostropheric stem cells, perhaps a new potential link between male body androgen levels and colon cancer, and using genetic or pharmacological attacks to regulate androgen levels in mice, the researchers found that higher androgen levels in the body promote faster intestinal stem cells than normal, and also induce a reduction in the production of mature cortical cells, a key feature of late tumor formation.
Interestingly, the results of this study also point out that this effect may not be direct, but is related to the surrounding habitat cells, habitat cells are a class of cells that regulate the growth and function of intestinal stem cells, of course, later researchers need to do more in-depth research, the results of this paper for later scientists by regulating the body's androgen levels to treat or inhibit the occurrence of colon cancer in men is very important.
() Original source: Xin Yu, Shiguang Li, Yiming Xu, et al. Androgen Maintenances Intestinal Homeostasis by Adding BMP Signaling via Intestinal Stromal Cells, Stem Cell Reports (2020) doi:10.1016/j.stemcr.2020.08.001.
