Stem Cell Rep: New study reveals neuronal characteristics in human hippocampus

, July 2, 2020 /PRNewswire/ --- In a recent study, neuroscientists and stem cell researchers at Lund University in Sweden have developed a research model that can study human hippocampusesThe study was published recently in the journal Stem Cell Reportsin Alzheimer's disease, the hippocampus structure of regulating motivation, emotion, learning and memory is severely affectedHowever, because of the lack of access to hippocampus, unless an autopsy is performed, researchers are unlikely to understand what the original events that cause disrecdes and subsequent neuronal damage areHowever, if we can understand which cellular pathways will change early in Alzheimer's disease, you can develop treatments that can slow down the disease(photo source:Lund researchers have succeeded in generating 3D hippocampus-like structures from induced pluripotent stem cells (iPSCs) (called hippocampuss (HS), which are rich in granular neuronsIn most vertebrates, including humans, new granular neurons are produced through a process called neurogenesis, which helps with memory formationscientists have developed new methods that will expand the production of hippocampus neurons to study human neurological occurrences and, most importantly, human hippocampus cells that study Alzheimer's disease and diseases,including granular neurons and glial cells that may be affected early on where the hippocampus is injured"By using patient iPSC, we can generate young brain cells and examine early pathogenic changes and gain insight into the development of brain disease," explains Laurent Roybon, director of the Center Ocyme Disease Modeling Stem Cell Laboratory at Lund University in"
researchers also used the model to examine cell dysfunction in Alzheimer's disease, or rather to examine how cells do not develop differently between individualsthey prepared the model from patients with extreme symptoms (amyloid precursor protein gene mutation in typical Alzheimer's patients, and a mutation in the early-age 1 gene in atypical individuals) and examined cytopathological characteristics" the model could be used to understand how hippocampus cells develop and mature over timeThey can also be used to check whether nerve neurogenesis in HS produced by hippocampus-damaged patients is affected compared to the control groupthe model can help reveal which cellular dysfunction occurs early in the disease and whether the same or different patients who carry familial or iexclusiveituatede forms areHS can be used to develop treatment options for patients and to understand why some treatments may be beneficial or detrimental to them (Bio Valley Bioon.com) source: New Model drifh shhubcampal neurons
original source: Pomeshchik, Y., et al (2020) Human ipsC-DerivEd Hippocampal Spheroids: An Innovative Tool for
The SP Stem Cell Reports doi.org/10.1016/j.stemcr.2020.06.001.