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    Home > Active Ingredient News > Drugs Articles > Standards to be followed in the construction of animal laboratories

    Standards to be followed in the construction of animal laboratories

    • Last Update: 2022-08-19
    • Source: Internet
    • Author: User
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     Animal experimentation is a long process of animal research, so that the research value of experimental animals has not only developed in biological sciences, but the editor of Botai will show you the standards that need to be followed in the construction of animal laboratorie.
    Construction of air system in animal laboratoryFresh air: preventing cross-contamination and deodorization are two major problem.
    For this reason, most of the air-conditioning systems must be purified by fresh ai.
    However, due to the large number of air changes in the purification system and the fresh air, the problem of energy consumption is prominen.
    Air purification system: Because the animal room is a place where experimental animals are active for a long time, it is impossible to sterilize the room by fumigation and washing under feeding condition.
    Generally, it can only be scrubbed with a weaker disinfectan.
    In order to avoid microbial infection, it is an important condition to ensure air purificatio.
    Deodorization: It is not only required by the facility for the external environment and staff, but also by the experimental animals themselves, because in addition to the external microbial pollution, the animal's own excrement and the secondary conversion of microorganisms into ammonia, hydrogen sulfide, alcohol, et.
    Gas is also an important pollutan.
    Standard requirements for animal laboratory constructionStrictly protect intellectual property rights and ensure the storage of dangerous good.
    The net floor height is too low, which affects the pipeline layout, and the space after decoration is lo.
    Design waste gas and waste water treatment systems to reduce harmful waste emission.
    Design rooms and rooms in the laboratory, controlled access control syste.
    The designed air shaft, or the position, size and quantity of the air shaft cannot meet the requirement.
    Establish a laboratory waste liquid recovery system and an intelligent control system to improve the efficiency of laboratory water and electricity utilizatio.
    Important rooms in the laboratory are not allowed to enter, and anyone in the public area can enter
    The construction should improve the comfort of the experiment, create a comfortable public environment for the laboratory personnel, and ensure the stable development of the laborator.
    Basic requirements for the construction of animal laboratorySite selection: secluded and hygieni.
    Water supply: There are drinking water and pure wate.
      Construction: clean corridors, breeding rooms, polluted corridors and other rooms are require.
      Air conditioning system: there are controllable temperature and humidity, airflow speed and distribution, and certain ventilation volume and air pressur.
      Lighting: Fluorescent lamps are used in animal rooms without windows, and glass windows can be installed in animal rooms with windows to filter out ultraviolet ray.
    Requires 12 hours light and 12 hours dar.
      Layout: It is divided into preparation area, feeding area and experimental are.
    The flow of people, logistics and animals is required to be separated, and purification and pest control are require.
      Precautions for the construction of animal laboratory According to the requirements of different types and levels of experimental animals, establish corresponding facilities, animal rooms, activity places and corresponding auxiliary room.
    The site should be selected in a place that is quiet, clean and does not affect the outside worl.
      The density of animals in the cage should not be too large, and there should be air supply, exhaust, cooling and thermal insulation equipmen.
    There must be special sewage and drainage facilities to prevent the spread of pathogen.
    All kinds of cages should be disinfected regularly, and the litter should be disinfected at high temperature and replaced in time, so that the indoor ammonia concentration is below one milliont.

      The animal room must be well lit, well ventilated, the ground is clean and free of water accumulation; the ceiling and walls must be easy to clean, and the exterior walls, roof, ceiling, doors and windows and pipes leading to the outside must be prevented from outside animals, mosquitoes and other insect pest.
    ente.
     Five, animal laboratory general environmental factor control range 1, humidity 45% ~ 55.
    The Ministry of Health stipulates that it is 40%~60%, and the airflow speed is 10~25cm/.
    Avoid direct blowin.
      The number of air changes is 6~15 times/.
    The fresh air is 2/3, the air pressure is positive pressure in the clean area, negative pressure in the infected area, and lighting is 150~300lx (artificial lighting.
       The environmental cleanliness level of the general animal breeding room is greater than 100,000.The noise is 40~50dB, 60dB when there are animals, and the Ministry of Health stipulates that it is less than 70d.
      The temperature target value is 21~27.
    Pharmacopoeia stipulates that it is 17~28.
    May vary by animal specie.

         
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