Sri Lanka Microorganism Announces Collaboration with Baidu Research Institute to Accelerate mRNA Vaccine and Drug Development with AI Empowerment

Artificial intelligence (AI) and biocomputing technologies are empowering research in the field of life sciences and accelerating the development of new drugs
.
mRNA platform technology stands out in the research and development of new crown vaccines, and the launch of two new crown mRNA vaccines also indicates that this cutting-edge technology will have a disruptive impact on the biomedical industry
.
With the deep integration of artificial intelligence technology and biology, medicine and other industries, mRNA technology will usher in a more vigorous development under the empowerment of AI
.
Previously, Baidu Research Institute and Siwei (Shanghai) Biotechnology Co.
, Ltd.
(hereinafter referred to as Siwei) cooperated on AI sequence optimization algorithms for the development of new crown mRNA vaccines, and developed efficient algorithms for designing and optimizing mRNA sequences.

.
The algorithm extends the concept of "word lattice parsing" in the field of natural language processing to the field of computational biology, and can quickly design a more stable and effective vaccine sequence for the new crown
.
Sri Lanka has completed the biological verification of this efficient algorithm in the molecular design of the new coronavirus mRNA vaccine
.
The results show that the new crown vaccine sequence designed by this algorithm is superior to the benchmark sequence designed by the traditional method in terms of stability, protein expression level and immunogenicity and other important indicators for measuring vaccines; the neutralizing antibody titer of the vaccine sequence ( One of the most important metrics for vaccines) is 20 times higher than traditional benchmark sequences
.
In addition to the new crown mRNA vaccine, the algorithm is suitable for the optimal design of various mRNA vaccines or drug sequences including infectious diseases, tumors and rare diseases
.
A few days ago, Sri Lanka Microbiology and Baidu Research Institute joined hands again.
The two parties will further improve the existing algorithm.
In addition to expanding the optimization of linear mRNA algorithm research, the two parties will try to develop circular RNA and other sequence design iteration technologies.
By improving the stability of mRNA It is expected to fully reflect the advantages of mRNA, that is, to improve efficiency, improve safety, and reduce production costs
.
Dr.
Li Hangwen, founder and CEO of Sri Lanka Microbiology, said: Applying AI technology to the field of biopharmaceuticals is conducive to creating an interdisciplinary drug research and development platform and is conducive to source innovation
.
mRNA sequence optimization with AI can help mRNA to express more proteins more stably
.
For the new coronavirus mRNA vaccine, the relevant algorithm can design a vaccine molecule that is stable and has a high protein expression level within 10 minutes, which effectively solves the problem of stability in the development of mRNA vaccines and speeds up vaccine development
.
Our combination with Baidu AI algorithm will also bring greater improvement to our pipeline and RNA platform under development, and is expected to launch more best-in-class products
.
This time, Sri Lanka and Baidu Research have expanded the research field to circular RNA, which will increase the stability of mRNA and translation efficiency, and at the same time increase the safety of drugs and vaccines
.
Circular mRNA is the hottest and most cutting-edge field of RNA research
.
The cooperation between the two parties has opened up new fields and is an innovative attempt
.
He believes that, compared with linear mRNA, circular mRNA is more stable, and the duration of action in the body is greatly prolonged.
At the same time, the performance of drugs developed with circular mRNA technology will be more superior, and the drug cycle will be extended, which is conducive to improving patients' acceptance of standardized treatment.
The compliance and convenience have broad prospects for future applications
.
According to Professor David Mathews of the University of Rochester, the related algorithm designed a set of sequences with more stable structure and used optimized codons
.
The efficient running speed of this algorithm is key to optimizing the design of sequences that can be experimentally tested for their efficacy as vaccines and drugs
.
The research and development and production of mRNA vaccines involve a number of key neck-neck technologies.
Siwei conducts self-research on each technology platform or cooperates with top institutions at home and abroad
.
This cooperation with Baidu has important strategic significance to lead the domestic mRNA technology to catch up with the world level
.
As the head mRNA vaccine and drug research and development enterprises, the strong cooperation between the two can drive the research and development of mRNA and the development of the overall industry
.