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Spotlight on Serological Markers to Explore Correlations Between Obesity and Prostate Cancer Risk

 Last Update: 2022-09-09
 Source: Internet
 Author: User

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leuprolide prostate cancer

ethical guidelines research

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Guided reading

The androgen and insulin-like growth factor-1 (IGF-1) regulatory axis is known to play critical roles in the progression of prostate cancer

The data and samples of this nested case-control study were derived from the large PCPT (SWOG-S9217) trial.

01The relationship between sex steroids and IGFs/IGFBPs and BMI

BMI was significantly associated with sex steroids and IGFs/IGFBPs

02Effect of sex steroids and IGFs/IGFPBs on obesity-related prostate cancer risk

Elevated BMI increased cancer risk in the high-risk group (OR=1.

Analysis conclusion

The present findings suggest that IGF-1 regulates axis-related serological markers, particularly IGFs and IGFBP2, that may influence obesity-related prostate cancer risk
.

More research is needed in the future to determine the role of these potential mediators, to understand the biological mechanisms associated with obesity and prostate cancer risk, and to help researchers and clinicians develop more effective prostate cancer prevention strategies and treatments
.

references:

Chau CH, Till C, Price DK, et al.
Serum markers, obesity and prostate cancer risk: results from the prostate cancer prevention trial.
Endocr Relat Cancer.
2022 Jan 20;29(2):99-109 .

Editor: Wang Mumu

Reviewer: LR

Executive: Wang Mumu

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