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The 40th JP Morgan Healthcare Conference will be held online from January 10-13, 2022
After acquiring Omniome last year for $800 million, PacBio noted that it plans to develop a new clustering method for use in conjunction with Omniome's sequencing-by-binding (SBB) method
The data presented by Henry shows that PacBio can achieve read lengths up to 200 bp with higher accuracy than Q40
The SBB technology also has "extremely low mismatch error rates, reaching true levels of variation between the sample and the reference genome," Henry says
This has important implications for oncology sequencing applications, where higher accuracy means fewer false positive variant calls
Henry noted that PacBio recently expanded its collaboration with Invitae to include an evaluation of the SBB platform in oncology
As PacBio moves to short reads, its main competitor Illumina is moving to long reads
For the new year, PacBio hopes that the popularity of HiFi sequencing solutions will propel the company to another level of success
PacBio will introduce new kits for the Sequel IIe system to reduce DNA input and reduce hands-on time
PacBio recently entered into a collaboration agreement with Twist Bioscience to develop targeted enrichment for HiFi sequencing