Spicy pot bottom or tomato pot bottom? Choose the food for Parkinson's disease away from you!

Parkinson's disease (Parkinson's disease, PD) is a common neurodegenerative disease, common among the elderly, the most important pathological change is the neurodegenerative death of the middle brain black dopamine (DA) neurons, which causes a significant reduction in the level of dysledo DA and disease.
1817, a detailed report on the disease was made by British doctor James Parkinson.
its clinical manifestations mainly include static tremor, movement retardation, muscle stiffness and posture gait disorders, while patients can be accompanied by depression, constipation and sleep disorders and other non-motor symptoms.
epidemiological studies have shown that smoking is associated with a low risk of PD, and nicotine plays an important role.
also have clinical studies that have shown that nicotine is expected to be an effective drug for Parkinson's disease.
nicotine as a alkaloid, not only in tobacco, but also in the fruits of a variety of aubergine plants, such as tomatoes, peppers, hazelnuts and so on.
, how does nicotine intake in the diet relate to the risk of Parkinson's disease? A recent paper published in The American Journal of Clinical Nutrition has for the first time conducted a large-scale, forward-looking study of the relationship between dietary nicotine intake in non-smokers and the risk of PD.
doi: 10.1093/ajcn/nqaa186 The study used data from two queues, one in the HPFS (Health Professionals Follow-up Study) queue, with 51,529 Male Health practitioners aged 40-75, and the NHS,1217 nurses aged between 30 and 55.
exclusion criteria are: 1. History of smoking; 2. Loss of follow-up, incomplete information; 3. Confirmed Parkinson's disease prior to analysis; 4. Total energy intake of 800 kcal/day or 4200 kcal/day.
the strict exclusion criteria were enforced, data from a total of 19,523 men and 31,615 women were included in the statistical analysis.
the study collected and calculated nicotine intake in the diet through the Food Frequency Questionnaire (FFQ).
to determine PD cases through questionnaires and to confirm them by reviewing medical records.
use the Cox Scale Risk Model to calculate the risk ratio (hazard ratio, HR) and the fixed effect model to calculate the combined risk ratio.
as shown in table 1, the study found 601 cases of PD during a 26-year follow-up study, of which 296 were for women and 305 in men. participants with high baseline nicotine intake in
diet were generally older, more physicalactivity, and more caffeine, alcohol, total carotenoids and total energy.
As shown in Table 2, eating more dietary nicotine is associated with a low risk of Parkinson's disease.
noteworthy, this significant negative correlation was only observed in the female population and no significant correlation was found in the male population.
article seduing two hypotheses that explain the apparent correlation between dietary nicotine intake and low PD risk: one hypothesis is that exposure to nicotine before the onset of PD affects choline regulation in the dopamine system in some way, thereby reducing disease progression.
this is also a classic hypothesis that many studies on the low risk of nicotine intake of smoking and PD have been put forward.
another new hypothesis that dietary nicotine reduces intestinal inflammation by altering the composition of the intestinal flora, which indirectly leads to a reduction in the misfolding of alpha-synaptic nucleoproteins before synapses in the central nervous system, reducing the risk of PD.
finally, the study concluded that eating nicotine and nicotine-rich foods such as tomatoes and chili peppers can reduce the risk of Parkinson's disease, and that the benefits of this dietary nicotine intake are particularly significant for women.
the insignificance of the correlation between male dietary nicotine intake and low risk of PD, the study concluded that a more comprehensive and accurate scale of nicotine dietary intake should be designed in the future to confirm the prevalence of this gender difference.
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