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Click on the blue text above to follow our first author: Li Xiao, Liu Hongsong Corresponding authors: Chen Hongxing, Yan Bo, Xie Lingtian Correspondence: South China Normal University Environmental Research Institute Paper DOI: 10.
1021/acs.
est.
1c03457 Picture summary Introduction to the results recently The team of Professor Xie Lingtian (Chemical Pollution and Risk Control Team) of the Environmental Research Institute of South China Normal University, Li Xiao, a PhD student, and Liu Hongsong, a master student, published a titled "Dietary Seleno-L" in the top journal Environmental Science & Technology in the international environmental field.
-Methionine Causes Alterations in Neurotransmitters, Ultrastructure of the Brain, and Behaviors in Zebrafish (Danio rerio)" research paper
.
The paper found that long-term exposure to food-phase selenomethionine (Se-Met) at environmentally relevant concentrations causes damage to zebrafish brain tissue, changes the metabolism of zebrafish brain neurotransmitters, and ultimately affects zebrafish behavior
.
The research results can strengthen the understanding of the toxic mechanism of selenium on fish, help establish/replenish potential adverse outcome pathways (AOPs) related to fish brain effects, and predict the impact of pollutants such as Se-Met on fish populations.
The phenomenon of fish extinction in the global selenium-polluted aquatic environment provides another possible evidence
.
Introduction Selenium is a trace essential element required by animals, and the range of difference between its basic and toxicity thresholds is very small
.
Selenium has received widespread attention as both a basic element and a toxic element
.
From the 1970s to the 1990s, scientific researchers in the United States, Norway and other countries discovered that a large number of fish and birds were extinct in the global selenium-polluted aquatic ecosystem
.
Studies have shown that excessive amounts of inorganic selenium are transmitted through the food chain/food web, which ultimately leads to the extinction of the top predators (such as fish and birds) in the aquatic food chain
.
The toxicity mechanism of excessive selenium mainly has two points: 1.
Se-Met is the main form of organic selenium.
After entering the organism, it can replace the methionine in the protein, causing protein folding errors, changing the structure and function of the protein, and then interfering with the organism’s Normal physiological functions; 2.
Metabolic activity after selenium enters the body will cause a large number of reactive oxygen species (ROS) to be produced, which will eventually cause changes in the structure of biological macromolecules such as protein, DNA and fat, and cause oxidative damage to fish
.
Fish behavior is essential to fish survival and population stability, and fish behavior is mainly regulated by neurotransmitters secreted by the central nervous system
.
Fish behavior has been paid more and more attention in the ecological risk assessment of chemicals
.
This study used target metabolomics and behavioral methods to investigate the effects of long-term exposure to food-phase Se-Met at environmentally relevant concentrations on the zebrafish nervous system and behavior
.
Graphic guide Figure 1 Excessive Se-Met accumulation leads to oxidative damage to the zebrafish brain.
The experimental results show that: Compared with the control group (C), it is medium (M: 12.
16 μg Se/g dry weight) and high (H: 34.
61 μg Se/ g Dry weight) The total selenium accumulation in the zebrafish brain tissue of the concentration treatment group increased, the ROS level increased, and the antioxidant enzyme activity and the expression of related selenoprotein genes decreased, which proved that Se-Met caused a decrease in the antioxidant capacity of zebrafish brain tissue
.
Figure 2 Excessive Se-Met causes brain mitochondrial damage.
According to the ultrastructure map of zebrafish brain tissue, it is found that, compared with group C, Se-Met causes swelling of brain mitochondria, rupture of ridge structure, and even membrane damage in group M and H , Matrix spillover
.
At the same time, the activities of mitochondrial respiratory chain complexes I, II, IV and V were significantly reduced in each treatment group
.
In addition, excessive selenomethionine also causes the endoplasmic reticulum of the brain to expand
.
Figures 3 and 4 Excessive Se-Met leads to changes in neurotransmitter signaling pathways and related genes in brain tissue.
Through the method of target metabolomics, we analyzed a total of 41 neurotransmitters and their metabolites, and the results showed that Compared with group C, zebrafish brain tissue is involved in the regulation of dopaminergic (DA), serotonergic (5-HT), acetylcholinergic (ACh), γ-aminobutyric acid (GABA) and histaminergic ( HA) These 5 neurotransmitter signaling pathways, a total of 21 neurotransmitters and their metabolites, are significantly affected
.
In addition, through qPCR quantitative analysis, it was found that the expression of related genes involved in the synthesis and transportation of these five pathways were also significantly affected
.
Figure 5 Excessive Se-Met leads to changes in zebrafish neurobehavior.
Compared with group C, after 60 days of feeding the selenium-containing feed in the M and H groups, the zebrafish’s free swimming ability and spatial cognition were significantly affected
.
Figure 6 AOPs prediction based on the effect of Se-Met on zebrafish neurobehavior.
Based on the results of this study, we summarized the adverse outcome pathways (AOPs) related to the zebrafish brain and neurotransmitters: the overproduction of ROS caused by Se can be seen It is the Molecular Initial Event (MIE), and the subsequent lipid peroxidation, rough endoplasmic reticulum expansion, mitochondrial damage, and changes in neurotransmitters and related genes are key events (Key Events, KEs).
The change in individual behavior is an undesirable result
.
The establishment of AOPs that Se-Met leads to zebrafish neurobehavioral changes can provide a scientific basis for assessing the ecological risks of various environmental pollutants to fish
.
This project was funded by the National Natural Science Foundation of China and the National Key Research and Development Project of the Ministry of Science and Technology
.
Introduction of the main author Corresponding author: Xie Lingtian, professor, doctoral supervisor, leading talent of the Environmental Research Institute of South China Normal University, member of the "Hundred Talents Program" of the Chinese Academy of Sciences, member of the International Society for Environmental Toxicology and Chemistry (SETAC) and the Chinese Society of Toxicology (CST)
.
Served as the associate editor of "Ecotoxicology", "Environmental Toxicology and Chemistry", "Environmental Pollution" and "Journal of Applied Ecology" and other international and domestic academic journals, and was selected as an expert in the Science and Technology Expert Database of the Ministry of Science and Technology
.
He has been engaged in research on the multi-source accumulation, migration and transformation and effects of chemicals and environmental pollutants (heavy metals and new organic pollutants) in aquatic organisms for a long time, and has achieved a series of leading research results at home and abroad.
Innovative projects and many other research projects, served as the co-chair of the Ecotoxicology, Monitoring and Assessment branch of the Sino-US Green Partnership Program bilateral seminar for many times, and was a special guest of the annual meeting of the China Association for the Advancement of Earth Sciences and the MERC meeting , Participated in the compilation of the third edition of the Chinese Encyclopedia-Ecology (Branch of Pollution Ecology and Toxicology Ecology)
.
He has published more than 50 papers in international academic journals such as "PNAS", "Environmental Science & Technology", "Environmental Pollution", "Aquatic Toxicology" and "Chemosphere"
.
Corresponding author: Yan Bo, professor, doctoral supervisor, winner of the Guangdong Provincial Outstanding Youth Fund for Natural Sciences, the first batch of "Guangdong Special Support Program" young top-notch talents in technological innovation, member of the Youth Innovation Promotion Association of the Chinese Academy of Sciences, concurrently serving as the utilization of environmental resources in Guangdong Province Deputy Director of the Key Laboratory of Environmental Protection, Member of the Environmental Protection Committee of the Chinese Rare Earth Society, and Director of the Guangdong Sustainable Development Association
.
Mainly engaged in waste/wastewater environmental protection treatment, ecological restoration and resource comprehensive utilization theory and technology research, and achieved some innovative results and understanding in the comprehensive utilization of tailings resources, soil heavy metal pollution restoration, industrial wastewater treatment and reuse and other fields
.
Presided over/completed more than 30 projects including the National Natural Science Foundation of China, the Chinese Academy of Sciences' pilot project, Guangdong Province’s key industry-university-research projects, and enterprise commissioned projects.
The relevant research results have published more than 60 research papers in core journals at home and abroad, and 10 authorized invention patents have been granted; In the combination of environmental engineering theory and practice, he has rich experience in environmental engineering technology design, implementation and management, presided over the completion of more than 10 wastewater/waste environmental protection projects, and won the second prize of China Nonferrous Metals Industry Science and Technology Award, Shaoguan Science and Technology Progress Second 1 prize each
.
The first author: Li Xiao, male, PhD student, currently studying in School of Environment, South China Normal University; Liu Hongsong, female, master student, currently studying in School of Environment, South China Normal University
.
Contribution: Xie Lingtian team of South China Normal University
.
For submission, cooperation, repost, and group participation, please add the editor Wechat Environmentor2020! Environmentor is the largest academic account in the environmental field, with nearly 10W active readers
.
Since WeChat has modified the push rules, please mark Environmentor as a star, or click on "Looking at" at the bottom of the page after reading each time, so that you can receive our daily tweets as soon as possible! There are more than 20 groups in Environmentor, including comprehensive groups, journal submission groups, fund application groups, study abroad application groups, and various research fields.
You are welcome to add to the editor WeChat Environmentor2020, and we will pull you into the corresponding group as soon as possible
.
Recommended papers recommended by ES&T Editor-in-Chief/Associate Editor-in-Chief: Why was my paper rejected without being submitted for review? Angew, Academician Qu Jiuhui of Tsinghua University: Restricted Enhancement Using Free Radical-led Fast Fenton-like Reaction Academician Hui ES&T: Green Fenton-Atomic Hydrogen-mediated Hydrogen Peroxide Hydroelectric Reduction Activation Process of Tongji University Zhao Hongying and Zhao Guohua Team ES&T: Electric Fenton Cathodic Oxidation-Reduction Synergistic Advanced Treatment of Halogen-containing Pollutants ES&T Team of Danish University of Science and Technology Zhang Yifeng: Conductive Research on the application of anaerobic granular sludge to sewage treatment and power generation.
ES&T, Hong Kong University of Science and Technology Lao Minci team: How to achieve the selective adsorption and removal of phosphate in water? ES&T Outlook: Professor Lin Shihong from Vanderbilt University: An intuitive understanding of the energy efficiency of the desalination process.
Wen Xianghua Team, School of Environment, Tsinghua University, WR: The biodegradability of wastewater determines the mechanism of construction of sewage plants microorganisms.
The team of Professor Lowry from Carnegie Mellon University AM: Sulfur content and morphology control the hydrophobicity, electron transfer, reactivity and selectivity of sulfided nano-zero-valent iron.
Academic recruitment Admissions for environmental engineering graduate program at Vanderbilt University (Ph.
D.
Master) Men Yu, Department of Chemistry and Environmental Engineering, University of California, Riverside The Jie research group recruits doctoral students (or post-doctoral) Dr.
Sam HY HSU research group, City University of Hong Kong School of Energy and Environment, Ph.
D.
The Environmental Molecular and Synthetic Biology Laboratory of the University of Notre Dame, the United States plans to recruit 2 full-awarded doctoral students Stockholm University, Sweden and Switzerland Eawag joint recruitment of full-awarded doctoral students (environmental direction) Professor Zhao Huazhang from the School of Environmental Science and Engineering of Peking University recruits Ph.
D.
academic information Yale University, Professor Julie B.
Wonyong Choi will be the founding editor-in-chief of ACS ES&T Engineering, Professor Wang Zimeng of the Department of Environment of Fudan University, will be the co-editor of Applied Geochemistry journal CEJ Advances | Interview with Academician Ma Jun, Deputy Editor-in-Chief of T Engineering: Environmental Science & Ecotechnology Editor-in-Chief Team! Scan the QR code to quickly join the group~
1021/acs.
est.
1c03457 Picture summary Introduction to the results recently The team of Professor Xie Lingtian (Chemical Pollution and Risk Control Team) of the Environmental Research Institute of South China Normal University, Li Xiao, a PhD student, and Liu Hongsong, a master student, published a titled "Dietary Seleno-L" in the top journal Environmental Science & Technology in the international environmental field.
-Methionine Causes Alterations in Neurotransmitters, Ultrastructure of the Brain, and Behaviors in Zebrafish (Danio rerio)" research paper
.
The paper found that long-term exposure to food-phase selenomethionine (Se-Met) at environmentally relevant concentrations causes damage to zebrafish brain tissue, changes the metabolism of zebrafish brain neurotransmitters, and ultimately affects zebrafish behavior
.
The research results can strengthen the understanding of the toxic mechanism of selenium on fish, help establish/replenish potential adverse outcome pathways (AOPs) related to fish brain effects, and predict the impact of pollutants such as Se-Met on fish populations.
The phenomenon of fish extinction in the global selenium-polluted aquatic environment provides another possible evidence
.
Introduction Selenium is a trace essential element required by animals, and the range of difference between its basic and toxicity thresholds is very small
.
Selenium has received widespread attention as both a basic element and a toxic element
.
From the 1970s to the 1990s, scientific researchers in the United States, Norway and other countries discovered that a large number of fish and birds were extinct in the global selenium-polluted aquatic ecosystem
.
Studies have shown that excessive amounts of inorganic selenium are transmitted through the food chain/food web, which ultimately leads to the extinction of the top predators (such as fish and birds) in the aquatic food chain
.
The toxicity mechanism of excessive selenium mainly has two points: 1.
Se-Met is the main form of organic selenium.
After entering the organism, it can replace the methionine in the protein, causing protein folding errors, changing the structure and function of the protein, and then interfering with the organism’s Normal physiological functions; 2.
Metabolic activity after selenium enters the body will cause a large number of reactive oxygen species (ROS) to be produced, which will eventually cause changes in the structure of biological macromolecules such as protein, DNA and fat, and cause oxidative damage to fish
.
Fish behavior is essential to fish survival and population stability, and fish behavior is mainly regulated by neurotransmitters secreted by the central nervous system
.
Fish behavior has been paid more and more attention in the ecological risk assessment of chemicals
.
This study used target metabolomics and behavioral methods to investigate the effects of long-term exposure to food-phase Se-Met at environmentally relevant concentrations on the zebrafish nervous system and behavior
.
Graphic guide Figure 1 Excessive Se-Met accumulation leads to oxidative damage to the zebrafish brain.
The experimental results show that: Compared with the control group (C), it is medium (M: 12.
16 μg Se/g dry weight) and high (H: 34.
61 μg Se/ g Dry weight) The total selenium accumulation in the zebrafish brain tissue of the concentration treatment group increased, the ROS level increased, and the antioxidant enzyme activity and the expression of related selenoprotein genes decreased, which proved that Se-Met caused a decrease in the antioxidant capacity of zebrafish brain tissue
.
Figure 2 Excessive Se-Met causes brain mitochondrial damage.
According to the ultrastructure map of zebrafish brain tissue, it is found that, compared with group C, Se-Met causes swelling of brain mitochondria, rupture of ridge structure, and even membrane damage in group M and H , Matrix spillover
.
At the same time, the activities of mitochondrial respiratory chain complexes I, II, IV and V were significantly reduced in each treatment group
.
In addition, excessive selenomethionine also causes the endoplasmic reticulum of the brain to expand
.
Figures 3 and 4 Excessive Se-Met leads to changes in neurotransmitter signaling pathways and related genes in brain tissue.
Through the method of target metabolomics, we analyzed a total of 41 neurotransmitters and their metabolites, and the results showed that Compared with group C, zebrafish brain tissue is involved in the regulation of dopaminergic (DA), serotonergic (5-HT), acetylcholinergic (ACh), γ-aminobutyric acid (GABA) and histaminergic ( HA) These 5 neurotransmitter signaling pathways, a total of 21 neurotransmitters and their metabolites, are significantly affected
.
In addition, through qPCR quantitative analysis, it was found that the expression of related genes involved in the synthesis and transportation of these five pathways were also significantly affected
.
Figure 5 Excessive Se-Met leads to changes in zebrafish neurobehavior.
Compared with group C, after 60 days of feeding the selenium-containing feed in the M and H groups, the zebrafish’s free swimming ability and spatial cognition were significantly affected
.
Figure 6 AOPs prediction based on the effect of Se-Met on zebrafish neurobehavior.
Based on the results of this study, we summarized the adverse outcome pathways (AOPs) related to the zebrafish brain and neurotransmitters: the overproduction of ROS caused by Se can be seen It is the Molecular Initial Event (MIE), and the subsequent lipid peroxidation, rough endoplasmic reticulum expansion, mitochondrial damage, and changes in neurotransmitters and related genes are key events (Key Events, KEs).
The change in individual behavior is an undesirable result
.
The establishment of AOPs that Se-Met leads to zebrafish neurobehavioral changes can provide a scientific basis for assessing the ecological risks of various environmental pollutants to fish
.
This project was funded by the National Natural Science Foundation of China and the National Key Research and Development Project of the Ministry of Science and Technology
.
Introduction of the main author Corresponding author: Xie Lingtian, professor, doctoral supervisor, leading talent of the Environmental Research Institute of South China Normal University, member of the "Hundred Talents Program" of the Chinese Academy of Sciences, member of the International Society for Environmental Toxicology and Chemistry (SETAC) and the Chinese Society of Toxicology (CST)
.
Served as the associate editor of "Ecotoxicology", "Environmental Toxicology and Chemistry", "Environmental Pollution" and "Journal of Applied Ecology" and other international and domestic academic journals, and was selected as an expert in the Science and Technology Expert Database of the Ministry of Science and Technology
.
He has been engaged in research on the multi-source accumulation, migration and transformation and effects of chemicals and environmental pollutants (heavy metals and new organic pollutants) in aquatic organisms for a long time, and has achieved a series of leading research results at home and abroad.
Innovative projects and many other research projects, served as the co-chair of the Ecotoxicology, Monitoring and Assessment branch of the Sino-US Green Partnership Program bilateral seminar for many times, and was a special guest of the annual meeting of the China Association for the Advancement of Earth Sciences and the MERC meeting , Participated in the compilation of the third edition of the Chinese Encyclopedia-Ecology (Branch of Pollution Ecology and Toxicology Ecology)
.
He has published more than 50 papers in international academic journals such as "PNAS", "Environmental Science & Technology", "Environmental Pollution", "Aquatic Toxicology" and "Chemosphere"
.
Corresponding author: Yan Bo, professor, doctoral supervisor, winner of the Guangdong Provincial Outstanding Youth Fund for Natural Sciences, the first batch of "Guangdong Special Support Program" young top-notch talents in technological innovation, member of the Youth Innovation Promotion Association of the Chinese Academy of Sciences, concurrently serving as the utilization of environmental resources in Guangdong Province Deputy Director of the Key Laboratory of Environmental Protection, Member of the Environmental Protection Committee of the Chinese Rare Earth Society, and Director of the Guangdong Sustainable Development Association
.
Mainly engaged in waste/wastewater environmental protection treatment, ecological restoration and resource comprehensive utilization theory and technology research, and achieved some innovative results and understanding in the comprehensive utilization of tailings resources, soil heavy metal pollution restoration, industrial wastewater treatment and reuse and other fields
.
Presided over/completed more than 30 projects including the National Natural Science Foundation of China, the Chinese Academy of Sciences' pilot project, Guangdong Province’s key industry-university-research projects, and enterprise commissioned projects.
The relevant research results have published more than 60 research papers in core journals at home and abroad, and 10 authorized invention patents have been granted; In the combination of environmental engineering theory and practice, he has rich experience in environmental engineering technology design, implementation and management, presided over the completion of more than 10 wastewater/waste environmental protection projects, and won the second prize of China Nonferrous Metals Industry Science and Technology Award, Shaoguan Science and Technology Progress Second 1 prize each
.
The first author: Li Xiao, male, PhD student, currently studying in School of Environment, South China Normal University; Liu Hongsong, female, master student, currently studying in School of Environment, South China Normal University
.
Contribution: Xie Lingtian team of South China Normal University
.
For submission, cooperation, repost, and group participation, please add the editor Wechat Environmentor2020! Environmentor is the largest academic account in the environmental field, with nearly 10W active readers
.
Since WeChat has modified the push rules, please mark Environmentor as a star, or click on "Looking at" at the bottom of the page after reading each time, so that you can receive our daily tweets as soon as possible! There are more than 20 groups in Environmentor, including comprehensive groups, journal submission groups, fund application groups, study abroad application groups, and various research fields.
You are welcome to add to the editor WeChat Environmentor2020, and we will pull you into the corresponding group as soon as possible
.
Recommended papers recommended by ES&T Editor-in-Chief/Associate Editor-in-Chief: Why was my paper rejected without being submitted for review? Angew, Academician Qu Jiuhui of Tsinghua University: Restricted Enhancement Using Free Radical-led Fast Fenton-like Reaction Academician Hui ES&T: Green Fenton-Atomic Hydrogen-mediated Hydrogen Peroxide Hydroelectric Reduction Activation Process of Tongji University Zhao Hongying and Zhao Guohua Team ES&T: Electric Fenton Cathodic Oxidation-Reduction Synergistic Advanced Treatment of Halogen-containing Pollutants ES&T Team of Danish University of Science and Technology Zhang Yifeng: Conductive Research on the application of anaerobic granular sludge to sewage treatment and power generation.
ES&T, Hong Kong University of Science and Technology Lao Minci team: How to achieve the selective adsorption and removal of phosphate in water? ES&T Outlook: Professor Lin Shihong from Vanderbilt University: An intuitive understanding of the energy efficiency of the desalination process.
Wen Xianghua Team, School of Environment, Tsinghua University, WR: The biodegradability of wastewater determines the mechanism of construction of sewage plants microorganisms.
The team of Professor Lowry from Carnegie Mellon University AM: Sulfur content and morphology control the hydrophobicity, electron transfer, reactivity and selectivity of sulfided nano-zero-valent iron.
Academic recruitment Admissions for environmental engineering graduate program at Vanderbilt University (Ph.
D.
Master) Men Yu, Department of Chemistry and Environmental Engineering, University of California, Riverside The Jie research group recruits doctoral students (or post-doctoral) Dr.
Sam HY HSU research group, City University of Hong Kong School of Energy and Environment, Ph.
D.
The Environmental Molecular and Synthetic Biology Laboratory of the University of Notre Dame, the United States plans to recruit 2 full-awarded doctoral students Stockholm University, Sweden and Switzerland Eawag joint recruitment of full-awarded doctoral students (environmental direction) Professor Zhao Huazhang from the School of Environmental Science and Engineering of Peking University recruits Ph.
D.
academic information Yale University, Professor Julie B.
Wonyong Choi will be the founding editor-in-chief of ACS ES&T Engineering, Professor Wang Zimeng of the Department of Environment of Fudan University, will be the co-editor of Applied Geochemistry journal CEJ Advances | Interview with Academician Ma Jun, Deputy Editor-in-Chief of T Engineering: Environmental Science & Ecotechnology Editor-in-Chief Team! Scan the QR code to quickly join the group~
