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A new study jointly led by the Barcelona Institute of Global Health (ISGlobal) supported by the “la Caixa” foundation shows that smoking during pregnancy is associated with changes in placental DNA methylation patterns, and many of these changes are in turn related to Poor fertility results are related
.
Cooperate with Emory University in Atlanta
In Europe, about one in ten mothers smoke during pregnancy
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Therefore, many health effects on the fetus are major public health issues
In this study, ISGlobal researcher Mariona Bustamante and her colleagues conducted a meta-analysis of 7 independent cohort studies of the PACE consortium to determine the impact of mothers’ smoking on the epigenome of the placenta.
These studies included Australia, France, and France.
1700 mother-baby pairs in Spain, Canada and the United States
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The meta-analysis identified 433 CpG sites that are related to mothers smoking during pregnancy, and nearly half of them are related to premature delivery and/or low body size or weight at birth
"The CpG sites, genes, and pathways identified in this study can help us decipher the mechanism by which smoking affects placental function and fetal growth," concludes Bustamante, a senior co-author of this study
Original search:
Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth
DOI
10.
