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SMC approves the first immunotherapy combination (Nivolumab combined with ipilmumab) for patients with rare-mutated advanced colorectal cancer

 Last Update: 2021-12-24
 Source: Internet
 Author: User

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Nivolumab combined with ipilmumab has been approved by the Scottish Medicines Federation (SMC) as a treatment option for adult patients for the treatment of patients who have failed previous fluoropyrimidine-based chemotherapy

Recently, Bristol-Myers Squibb (BMS) announced that the Scottish Pharmaceutical Union (SMC) has accepted Nivolumab in combination with ipilmumab as a late mismatch repair defect (dMMR) or high microsatellite instability (MSIH)Treatment options for adults with colorectal cancer , these patients have failed previous fluoropyrimidine-based chemotherapy, and the therapy is used by the NHS in Scotland

Colorectal cancer

This group of patients is characterized by a rare genetic mutation called MSI-H or dMMR, which affects how the cancer grows

diagnosis

The median age of the treated patients was 66 years (N = 45)

The objective response rate and disease control rate were 69% (95% CI, 53 to 82) and 84% (95% CI, 70.

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