Signet ring cell carcinoma again!

For medical professionals to read and reference gastric signet ring cell carcinoma is one of the highly malignant tumors.
The day before yesterday, I saw the news forwarded by a friend: a 28-year-old girl died of stomach cancer; I was very sad
.

I'm not familiar with this girl, and I found out that the girl's name is Su Riman, and she is a promising girl from Inner Mongolia! She is the ambassador of cultural tourism in Hohhot City, and she is also a very good young dancer.
She has won the 2014 Miss Tourism Championship, the silver award of the "Lotus Award", the highest award of Chinese dance, and other honors
.

However, in July 2021, when it bloomed brilliantly, he was diagnosed with advanced gastric cancer
.

At that time, multiple bone metastases had already occurred, and he soon lost the ability to walk independently.
He could only sit in a wheelchair and rely on his parents to push him around.
Even the usual eating and drinking became a problem, so he could only rely on his parents.
Putting food in your mouth will solve the problem
.

In order to live strong, she actively cooperated with the treatment, and spent her 28th birthday in chemotherapy.
She underwent 8 chemotherapy treatments in 8 months, endured the pain that ordinary people cannot understand, and finally, she lost to cancer; Just three days ago, a beautiful soul still drifted away.
.
.
just 28 years old! A good girl with great talent and love, all the happiness she should have came to an abrupt end, and she went like this.
.
.
Parents who are heartbroken, the white-haired person sends the black-haired person, the most human tragedy! Beautiful girl, may there be no more pain, no more regrets.
.
.
Let the world remember your beautiful appearance! In clinical practice, the author has also met more than a dozen such young women.
From diagnosis to death, between 3 months and a year, the youngest was only 23 years old when he died
.

This is the notorious, highly malignant form of gastric signet ring cell carcinoma that occurs mostly in young and middle-aged women
.

I think it is necessary to briefly introduce this terrible devil to everyone! (Case: Anti-Cancer Bi Shuo, Author: Bi Xiaofeng) Overview Gastric signet ring cell carcinoma is one of the highly malignant tumors, accounting for about 9.
9% of gastric cancer
.

Gastric cancer is divided into papillary adenocarcinoma, tubular adenocarcinoma, mucinous adenocarcinoma, signet ring cell carcinoma, adenosquamous carcinoma, squamous cell carcinoma, and undifferentiated carcinoma
.

Among them, signet ring cell carcinoma is a special type of gastric cancer that contains a lot of mucus.
Because the cells are full of mucus, the nucleus is squeezed to one side of the cell, making it look like a ring, hence its name
.

The disease mostly occurs in young and middle-aged women, especially young women.
Most experts believe that the occurrence of this disease may be related to the vigorous metabolism of estrogen in young women
.

Gastric signet ring cell carcinoma is the least optimistic type of gastric cancer.
Signet ring cells are filled with mucus, and the nucleus is squeezed to one side, and the shape is the same as a ring
.

Sometimes it is difficult to detect by gastroscopy, it quietly infiltrates in the submucosa, there may be a little erosion on the surface, and the bottom is very advanced.
Signet ring cell carcinoma of the stomach will cause a leather stomach, making the stomach smaller and stiffer, unable to shrink, and the course of the disease.
Progress is very fast
.

Classification In 2000, the World Health Organization defined gastric signet ring cell carcinoma as: scattered or small clusters of malignant tumor cells containing mucus in the cytoplasm, accounting for more than 50% of tumor cells
.

According to the cell morphology, it is divided into 5 types: classic type (type I), histiocytoid type (type II), eosinophilic type (type III), small cell type (type IV), and anaplastic cell type (type II).
Type V)
.

There are no obvious symptoms in the early stage, and some patients may have indigestion, such as epigastric discomfort, abdominal pain and bloating, early satiety after meals, loss of appetite, acid reflux, belching, nausea and vomiting, hyperactive bowel sounds, increased exhaust, abnormal stool, etc.
, easily missed
.

In the advanced stage, there may be abdominal mass, ascites, weight loss and so on
.

Gastric signet ring cell carcinoma shows diffuse invasive growth, and is often accompanied by obvious fibrosis (sclerosis).
Middle and late
.

Diagnostic gastroscopy and pathological examination are effective and reliable methods for early diagnosis of gastric signet ring cell carcinoma
.

Treatment includes endoscopic therapy, surgery, chemotherapy, biological immunotherapy, and traditional Chinese medicine
.

Signet ring cell carcinoma is not sensitive to chemotherapy, and the effect of chemotherapy is poor.
At present, surgery is still the first choice
.

If it can be diagnosed early and operated early, the 5-year survival rate after surgery is significantly higher than other types of gastric cancer
.

Surgical treatment is not recommended for advanced signet ring cancer, because signet ring cancer is prone to diffuse invasive growth in the stomach wall, penetrate the stomach wall, and directly spread to the peritoneum or adjacent organs.
Accelerates disease progression
.

For those who are diagnosed with advanced gastric signet ring cell carcinoma, the method of integrated traditional Chinese and Western medicine can be used to relieve the condition, relieve pain and prolong life
.

Biological immunotherapy is mainly based on DC-CIK cells.
DC and CIK cells are the immune cells with the strongest recognition and tumor killing effects in the human body
.

After surgery, patients are often unable to completely remove cancer cells, and there will still be cells remaining in the blood and lymph, which become the root cause of tumor recurrence and metastasis
.

If combined with biological therapy after surgery, DC and CIK cells will directly find residual cancer cells and eliminate them directly, avoiding the hidden danger of recurrence
.

Similarly, latent cells and insensitive cells that cannot be killed by radiotherapy and chemotherapy can be removed, which can also reduce the side effects caused by radiotherapy and chemotherapy
.

Advantages of biological immunotherapy: 1.
It can effectively remove residual tumor cells and small lesions after tumor surgery, radiotherapy and chemotherapy, and prevent tumor recurrence and metastasis
.

2.
It can enhance the sensitivity of tumor radiotherapy, reduce the toxic and side effects of radiotherapy; resist the immunosuppressive effect of chemotherapy drugs, enhance the sensitivity to chemotherapy drugs, and improve the efficacy of chemotherapy
.

3.
Cellular immunotherapy is the only option for patients with advanced tumors who have lost the opportunity for tumor surgery and who are ineffective in radiotherapy and chemotherapy.
Cellular immunotherapy is painless, can quickly relieve their symptoms, and patients can achieve long-term survival
.

Although the factors that determine the prognosis of gastric cancer are related to the cell type, they are more related to the depth of the cancer foci and the degree of lymph node metastasis, that is, the stage of the cancer
.

If early detection, early diagnosis, and early treatment can be achieved, gastric signet ring cell carcinoma is the same as other types of gastric cancer, and the prognosis is very good
.

Even in the middle and late stages, as long as you have a good psychological quality and a strong will to overcome the disease, and actively accept the correct comprehensive treatment, the prognosis will not be worse than other types of gastric cancer
.

In fact, gastric signet ring cell carcinoma is only a pathological type of gastric cancer, not its biological behavior
.

In the past, some people have confused gastric signet ring cell carcinoma with undifferentiated carcinoma and diffuse gastric cancer, but they are not exactly the same
.

It is worth noting that this special type of gastric cancer has been on the rise in recent years.
It is reported that gastric signet ring cell carcinoma accounts for more than 30% of the total gastric cancer, which is about 10 times higher than that before 2000
.

Due to the type of advanced gastric cancer patients, especially the so-called "leather stomach" diffuse invasive gastric cancer, many pathological types are gastric signet ring cell carcinoma, which makes people mistakenly think that they have gastric signet ring cell carcinoma, and the effect is very poor
.

In fact, the prognosis of gastric cancer is mainly related to the staging.
To be precise, it is the TNM staging.
Simply put: the depth of tumor invasion, the number of lymph node metastasis, and whether there has been distant metastasis such as the liver and abdominal cavity.
Only these three indicators can truly determine a gastric cancer.
patient prognosis
.

At present, a large number of literatures show that in early gastric cancer, the effect of gastric signet ring cell carcinoma is better than other types of gastric cancer, and the lymph node metastasis is less; in advanced gastric cancer, many scholars believe that pathological The prognosis of patients with intermediate and advanced gastric signet ring cell carcinoma is relatively poor; however, some literatures believe that the prognosis of gastric signet ring cell carcinoma and non-signet ring cell carcinoma is not much different in the same stage
.

Only the TNM stage is the determinant of the effect
.

Regarding prevention, the etiology of this disease has not been completely clear so far, so prevention is a commonplace; everyone must know it; however, the most important thing is that the cure rate is still very high with early inspection and early detection
.

There are no obvious symptoms in the early stage of the disease, but some patients may have indigestion, such as epigastric discomfort, abdominal pain and bloating, early satiety after meals, loss of appetite, acid reflux, belching, nausea and vomiting, hyperactive bowel sounds, increased farting, abnormal stools, etc.
easy to miss
.

In the advanced stage, there may be rapid abdominal swelling, ascites, weight loss,
etc.

Gastric signet ring cell carcinoma shows diffuse invasive growth, and is often accompanied by obvious fibrosis (sclerosis).
Middle and late
.

So don't wait until you have symptoms to get a gastroscope
.

Gastroscopy and pathological examination are effective and reliable methods for early diagnosis of gastric signet ring cell carcinoma
.

However, due to the early stage of the disease, even with gastroscopy, the missed diagnosis rate is as high as 40%.
Therefore, young people, especially those with a family history of cancer, should pay attention to the combined examination-gastroscopy + tumor markers if they experience stomach discomfort + Genetic testing,
etc.

90% of gastric cancers are intestinal-type gastric cancers, which are gastric cancers with Helicobacter pylori infection as the main cause.
It is relatively easy to detect.
Diffuse gastric cancers are relatively rare, and everyone should not be obsessed.
Most people only need to eradicate Helicobacter pylori and pay attention to their living habits.
You won't get stomach cancer; secondly, even if you find out gastric signet ring cell cancer, you don't have to worry too much
.

Active cooperation with treatment will also have a better prognosis
.

Source of this article: Gastroenterology Author of this article: Lao Du Responsible editor: XU Copyright Statement This article is reprinted and welcome to forward it in the circle of friends-End-The medical community strives to be accurate and reliable when the published content is approved, but it does not regard the timeliness of the published content.
and the accuracy and completeness of the cited information (if any), and does not assume any responsibility for the outdated content, possible inaccuracy or incompleteness of the cited information,
etc.

Relevant parties are requested to check separately when adopting or using it as a basis for decision-making
.