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On November 3, 2021, Peking University's Wei Wensheng's group and Chinese Academy of Medical Sciences/Peking Union Medical College Wang Jianwei's group jointly published a titled Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV in Signal Transduction and Targeted Therapy .
The 2019 novel coronavirus disease (COVID-19) caused by the new coronavirus infection has severely affected human health and social stability, but its pathogenic mechanism is still unclear
The new coronavirus is a type of RNA virus, which is usually recognized by the host RIG-I-like receptor (RLR) and activates the interferon response
In order to further study the relationship between the cell fusion induced by the new coronavirus and the activation of natural immunity, Wei Wensheng's group established a cell fusion system mediated by the interaction between the viral spike protein Spike and the viral receptor ACE2
Figure 1.
The classic paradigm of innate immune response is a specific response to pathogen invasion after the body recognizes and distinguishes "self" and "non-self" components
Associate researcher Zhou Zhuo of Wei Wensheng's research group is the co-first author and co-corresponding author of the paper.
Paper link:
https://
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