Shocked! Do blood sugar levels affect a person's susceptible to coronavirus?

!-- webeditor: page title -- May 2, 2020 / / - Does observing your blood sugar help fight COVID-19? Sugar is more than just something that sweetens food.
it is also an important part of the protein that makes up our body.
control blood sugar through diet and exercise, as well as better control of blood sugar in diabetics, especially when suffering from COVID-19, may help control the severity of the disease, or even its spread.
M. Brufsky has been working in breast cancer for many years, and he and his colleagues have been trying to use a drug called hydroxychloroquine in clinical trials.
goal is to reduce the number of breast cancer cells in the bone marrow and prevent them from re-emerging years later, leading to relapse -- known as tumor hibernation.
: In recent months, you may have heard a lot about the antimalarial drug hydroxychloroquine, which is recommended for the treatment of COVID-19.
so far there is no conclusive evidence that hydroxychloroquine is effective.
, hydroxychloroquine has been found to lower blood sugar like metformin.
Brufsky's colleagues say many of their COVID-19 patients not only have diabetes, but some are undiagnosed.
understand that the drug has the potential to lower blood sugar, coupled with reports of high blood sugar in patients with COVID-19, allowed Brufsky to combine the two to try to explain some of the conditions with COVID-19 and how blood sugar interacts with the virus.
does the virus get into cells and how does it affect blood sugar? The new coronavirus infects cells by attaching them to the surface of the cell through a subject called angiosin-converting enzyme 2 (ACE2).
ACE2 and viruses require sugar molecules that bind to proteins to function properly.
his idea is that COVID-19 infection and its severity are affected by the concentration of the virus wrapped in sugar in the lung tissue and the concentration of the sugar-modified ACE2 subject, as described in a peer-reviewed article by Journal of Medical Virology.
about 8 to 10 days after symptoms begin, the degree and control of the lung immune response may also depend on how much sugar is attached to the virus's prickly protein, which may depend on your age and gender researchers already know that people with diabetes are more likely to develop COVID-19.
Unusually, when Brufsky spoke to doctors across the country who treated COVID-19 patients, he found that many of the patients in their hospitals were not only diabetic or prediabetes, but also had unknowingly high blood sugar levels.
recently, a report in Wuhan found this out.
sars associated with the new coronavirus appear to experience temporary hyperglycemia after infection.
this makes sense because there are many ACE2 subjects on so-called islet cells.
these are the cells that make insulin, which is essential for controlling blood sugar.
if the virus infects these cells, they stop secreting insulin and you develop temporary COVID-19 diabetes, " he said.
photo source: High blood sugar increases ACE2 in the lungs of diabetic mice.
so not only does the number of subjects increase, but they also attach more sugar.
makes the virus more susceptible to cell infection.
when there is more insulin, or when blood sugar levels are lowered through diet or exercise, the ACE2 subject and the sugar on each subject are reduced, which may reduce the number of viruses entering the cell.
suggests that a high blood sugar test called hemoglobin A1c -- even for those without diabetes or prediabetes -- could be used as a marker for patients at risk of COVID-19 disease.
fact, 3.8 percent of Americans have a high level of A1c.
is hydroxychloroquine involved? Hydroxychloroquine may work by blocking the process of adding sugar to proteins in cells.
this is the opposite of high blood sugar.
theory, this would prevent the virus from interacting with its subjects and regulate the inflammatory response to the virus.
it is not clear whether hydroxychloroquine is suitable for all or only a small number of patients.
while the medical community is waiting for clinical trials to tell us whether hydroxychloroquine can help COVID-19 patients.
but interesting to Brufsky, the debate may lead to assumptions about why high blood sugar can worsen the disease and what might be done to help patients.
many new drugs and theories about COVID-19 are emerging and science is developing rapidly.
it's important to have theories to explain what you see clinically and scientifically and see if they fit -- and then test them.
if it doesn't work, try to change your mind.
this kind of thinking and testing that allows us to beat COVID-19.
() Reference: 1. Blood sugar levels may influence influence to coronavirus 2 Elevated A1C in Adults Without a History of Diabetes in the U.S. 3" Characterization of ACE and A CE2 Expression within Different Organs of the NOD Mouse (4) Binding of SARS coronavirus to its receptor damages islets and acute causes diabetes (5) Blood glucose levels in elderly subjects with type 2 diabetes. when COVID-19 outbreak: a retrospective study in a single center !--/ewebeditor:page--!--ewebeditor:page?"""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""""ACE2 Gene Expression and Regulation (7) The effect of hydroxychloroquine on glucose control and insulin resistance in the prediabetes condition (8) A Phase II Pilot Trial of Hydroxy Choroquine, EV Erolimus. Or the Configuration for Prevention of Recurrent Breast Cancer (9) Hyperglycemia, Hydroxychloroquine, and the COVID-19 Appa 10 Clinical Features of 138 Partners Patients With 2019 Novel Coronavirus-Infected Pneumonia in In Wuhan, China !--/ewebeditor:page.