Shikimic acid in star anise can inhibit thrombosis

The commonly used flavoring star anise contains a substance called shikimic acid, which has antithrombotic activity This is the conclusion of a scientific research project that won the second prize of science and technology award of Chinese Academy of traditional Chinese medicine in 2010 The research was completed by sun Jianning, Guo Yajian, Xu Qiuping, etc of Beijing University of traditional Chinese medicine It was found that shikimic acid, which is extracted from aniseed of Magnoliaceae, has antithrombotic activity for the first time, and it is related to its effect on arachidonic acid metabolism, inhibition of platelet aggregation and inhibition of coagulation system Since then, in order to improve the liposolubility of shikimic acid and find bioactive compounds, researchers have successively synthesized 11 derivatives of shikimic acid, and found that triacetyl shikimic acid and isopropylidene shikimic acid (ISA) have strong antithrombotic activities, established the preparation process, structure identification, content determination method, and conducted safety evaluation Around the problems of preparation process, purity, quality control and safety, the researchers found that isa preparation process is simple, yield is high, purity is good, content determination method is simple, accurate, quality is controllable, safety range is large, and has good drug resistance After the optimization of chemical technology, the project team processed isa into tablets and formulated corresponding quality standards The combination of quantitative and qualitative methods ensured the stability and controllability of the drug Isa has independently applied for two patent protections for its preparation and use The pharmacodynamic study shows that the compound has the advantages of strong antithrombotic effect and inhibition of inflammatory cascade reaction caused by ischemia, and has good protection and repair effect on nerve injury of hippocampus The mechanism of action has been preliminarily clarified In the behavioral index, ISA has the advantages of good efficacy, wide safety range and less adverse reactions, and has a good application prospect 。 Therefore, the project team proposed the indications of ISA in the treatment of vascular dementia The project has been evaluated by many pharmaceutical companies and signed a development and research agreement The expected economic and social benefits are good.