Shenzhen Advanced Institute developed a new model of rose petal nerve interface device.

Neurostimulation techniques have attracted much attention because of their remarkable effect on the treatment of neurological disorders such as Parkinson's disease, epilepsy, blindness and depression.
traditional implantable nerve devices are usually prepared with composite materials such as metals, organic matter and polymers, but because of their differences in biological tissue performance, implantation is easily considered as a foreign body and causes inflammatory reactions, which eventually lead to the device being wrapped in fibrosis tissue and the death of neurons around the implant.
in response to this problem, the research team of Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences (hereinafter referred to as Shenzhen Advanced Institute) developed a neural interface device with microcone array structure, after mouse testing, can significantly promote the attachment and climbing of neuronal synapses (like mountain-like tiger behavior), as well as the construction of periodic neuronnetworks, not only greatly improve the biocompatibility and effectiveness of nerve device implantation, but also provide new strategies and methods for neuron network reconstruction and function regulation. On July 27,
, the results were published in Microsystems and Nanoengineering, an authoritative journal in the field of engineering.
Chen Hongxu, Wang Wei as the co-first author, Du Xuemin and Lu Yi as co-communication authors, Shenzhen Advanced Institute as the only communication unit.
", the human body is very sensitive to implantable devices and has a strong response once implanted.
" Du Xuemin said that inflammation and neuron necrosis can affect the performance of nerve devices in the process of chronic implantation, seriously hindering the widespread use of neurostimulation technology.
Therefore, how to reduce the inflammatory reaction of neural device interface and achieve long-term effective stimulation is the key problem that implantable neural devices need to be solved urgently.
in response to existing challenges, based on the evidence in previous studies that micro-nastructures can regulate cell behavior, the team put forward a hypothesis that nerve devices can be used to achieve long-term anti-inflammatory effects through a microscopic physical structure. The unique structure of the rose petals inspired the team. The
research team arranged the colloidal microspheres on the substrate, etched the sphere by ion etching, and then prepared a microcone array structure unique to the surface of the rose petals, and designed the special structure prepared by the colloidal crystal etching method to the surface of the nerve device.
in the validation experiment, the researchers first placed implanted nerve devices with micro-macro structures into a medium containing nerve cells, and observed that neuronal cells, after exposure to the micro-nastructure, promoted the growth of neuronal synapses and formed a unique periodic neural network.
when tissue is damaged, astrocytes are activated immediately and parcels of the affected or implanted devices through mass proliferation to prevent other tissues from being harmed.
"traditional implanted nerve devices to reduce the incidence of inflammation by wrapping anti-inflammatory drugs, the effects of anti-inflammatory are very limited.
" Lu yi said, and in a six-week experiment on chronic implanted mice, the team found that the new formation of these types of structures can hinder the formation of the attachment and tissue sacs of astrocytes, thus confirming that implanted nerve devices with micro-namorphic appearances have excellent anti-inflammatory properties.
the study effectively reduces inflammatory reactions and promotes neuron networking through its unique physical structure, not only guarantees long-term implantation and effective stimulation of nerve devices, but also provides new strategies and methods for rebuilding neuron network and regulating neural function, and has a good application prospect in implantable medical devices.
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