Shengbai needle is often used, do you know these common adverse reactions?

Shengbai needle, recombinant human granulocyte colony-stimulating factor (G-CSF), its role is to promote the immature neutrophils in the bone marrow to mature, differentiate and proliferate as soon as possible, and spread to the peripheral blood to increase the leukocyte coun.

Bone pain

G-CSF-related bone pain is one of the common side effects, and the exact mechanism of bone pain is unknow.

An important reason is currently believed to be related to the increase in histamine caused by the immune response induced by G-CSF treatment, because the release of histamine can cause edema and pain in the bone marro.

Most literatures believe that the bone pain of short-acting and long-acting white needles occurs in about 24-31% of patients, but there are also literatures that it can be as high as 66.

At present, there is no special recommendation for the choice of analgesic drugs for bone pai.

In addition to taking pain medication, what other ways are there to help with bone pain?

The antihistamines currently recommended are: famotidine (Gasocitabine) and loratadine (Cerritan), both of which are very simple and safe drugs, and are indeed effective against It is effective for bone pain, but of course it is completely ineffective for pain such as bone metastase.

A clinical case is as follows: A 67-year-old ovarian cancer patient developed neutropenia after chemotherapy with paclitaxel combined with carboplatin, requiring the use of long-acting white needles, resulting in extremely severe pain, mainly from the legs to the fee.

Second, the white blood cell count fluctuates up and down

After the white blood needle was administered, the increase in white blood cells was bimoda.

The first peak is the result of promoting the release of mature white blood cells in the body to the peripher.

In the second peak, the white blood needle stimulates the bone marrow to generate new white blood cells and release them into the peripheral bloo.

sweet syndrome

Another complication of Shengbai Needle is sweet syndrome, also known as neutrophilic dermatiti.

Fourth, the second tumor risk

After applying G-CSF, the white blood cells rise so high, will the patient develop leukemia or similar diseases (such as MDS, that is, myelodysplastic syndrome)? This concern is not groundles.

For patients receiving G-CSF after chemotherapy, the problem is compounde.

However, even with a slightly increased risk of leukemia in these patients (8% v.

Rupture of the spleen

Among the side effects of Dashengbai injection, there are also case reports of spleen rupture, and the exact mechanism is still unclea.

In general, for patients with bone marrow suppression after chemotherapy, the immunity is low, and the whole body is open to various potential danger.

How to choose short-acting or long-acting whitening needles?

Short-acting: short-acting time, used 24-48 hours after chemotherap.
It needs to be injected every day, and blood is drawn every 2-3 days to review the white blood cell.
If it is still low, continue to inject until it rises to normal or close to norma.
The price is about 100-300 yua.

Long-acting: It is used within 48 hours after the end of chemotherap.
It is injected only once, and the action time can last for 2 week.
Frequent blood tests are not require.
The price is around 1700-5000 yua.

Attachment: Precautions for common whitening drugs and whitening needles