Shanghai Jiaotong University Li Dan's group and collaborators discovered and characterized a novel pathological protein fiber aggregate formed by TMEM106B in the human brain

Pathological protein fibrous aggregates formed by pathological proteins through liquid-solid phase transition are important pathological markers of various neurodegenerative diseases (NDs)

On April 27, 2022, Li Dan's research group, associate professor appointed by the Dean of Bio-X Research of Shanghai Jiao Tong University, cooperated with Wang Jian's research group of Huashan Hospital Affiliated to Fudan University, and Liu Cong's research group of Shanghai Institute of Organic Chemistry Interdisciplinary Research Center in Cell Research .

Li Dan's group has long been devoted to studying the molecular mechanism of the liquid-solid phase transition and aggregation of α-synuclein (α-syn), a key protein in Parkinson's disease, and developing new methods for chemical intervention and tracing

Figure 1.

More interestingly, in addition to the brain tissue of PDD patients, the researchers also obtained the same protein fiber aggregates formed by TMEM106B from the brain tissue of two other elderly healthy controls

Figure 2.

It is worth mentioning that Cao Li, an associate professor of our dean's teaching track, recently published a similar discovery in Nature1 (https://mp.

Figure 3.

In conclusion, this study unexpectedly discovered a new type of pathological fibrous aggregates formed by TMEM106B protein from the midbrain tissue of PDD patients and aged healthy controls, and discussed the direct relationship between the formation of TMEM106B fibers and disease and aging

Zhao Qinyue, a graduate student of the Bio-X Research Institute of Shanghai Jiao Tong University, is the co-first author of the paper.

Article link: https://#Sec1

references:

1.

2.

3.