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Shanghai Jiaotong University He Guang's research group and Lu Qing's research group jointly analyzed the structure and function of the heterozygous variant of ARID4A, a new candidate gene for schizophrenia

 Last Update: 2022-05-10
 Source: Internet
 Author: User

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Recently, "Molecular Psychiatry" published online with the title "A novel heterozygous missense variant of the ARID4A gene identified in Han Chinese families with schizophrenia-diagnosed siblings that interferes with DNA-binding activity" by He Guang, Bio-X Institute of Shanghai Jiaotong University.

Figure 1 Article home page

Figure 2 Results of functional studies of ARID4A protein analysis and mutation

(a) Ribbon diagram of PWWP-ARID structure; (b) DNA-binding functional analysis of the protein; (c) Effect of gene mutation on cell proliferation and cell cycle

Schizophrenia is a severe chronic mental disorder that severely affects an individual's behavior and its cognitive and emotional processes

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