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*It is only for medical professionals to read for reference.
Which drugs will affect sexual function? The first thing to emphasize is that more than 80% of men with erectile dysfunction (ED) have organic causes.
The most common vascular cause is penile arteriosclerosis.
Hypertension and diabetes are very important risk factors for atherosclerosis
.
In addition, mental factors such as depression and severe anxiety can also lead to male erectile dysfunction
.
However, it is an indisputable fact that certain drugs can cause erectile dysfunction in men
.
Understanding the drugs that affect sexual function can be used selectively during diagnosis and treatment, and can improve patient compliance with medication
.
1.
Antihypertensive drugs 1.
Representative drugs of thiazide diuretics: hydrochlorothiazide, indapamide, chlorthalidone
.
Many studies have shown that diuretics are the antihypertensive drugs that have the greatest impact on male sexual function, including decreased libido, erectile dysfunction, and difficulty ejaculation
.
In different studies, the incidence of such side effects was 3% to 32%
.
Possible mechanisms: diuretics cause blood volume reduction; diuretics reduce the response of vascular smooth muscle to catecholamines; diuretics increase urinary zinc excretion, and zinc deficiency leads to a decrease in progesterone synthesis.
Adding zinc therapy can improve the sexual function of some patients
.
2.
Representative drug of aldosterone receptor antagonist: spironolactone
.
Long-term use of spironolactone can cause decreased male libido and erectile dysfunction
.
Possible mechanism: The structure of spironolactone is similar to progesterone.
It binds to the androgen receptor and inhibits the action of androgen.
At the same time, it inhibits 17α-hydroxylase and reduces the production of testosterone.
.
3.
β- blockers behalf drugs: propranolol, metoprolol, bisoprolol, atenolol, carvedilol and so on
.
A meta-analysis found that for every 199 patients with beta blockers for every 1 year, an additional patient with erectile dysfunction (ED) was added
.
Possible mechanism: After β-blockers, the activity of peripheral vascular α receptors is relatively enhanced, causing vasoconstriction, resulting in a decrease in blood flow into the penis; studies have also found that after the application of β-blockers, the patient's serum testosterone The level has declined
.