Several studies focus on new advances in obesity research!

In this paper, the small editor compiled a number of important research results, together to analyze the recent progress made by scientists in the field of obesity research, share to everyone! Photo credit: Science, 2020, doi:10.1126/science.aaz8995 (Science: Chinese and U.Sscientists work together to analyze the three-dimensional structure of MC4R to help develop a new anti-obesity drug doi: 10.1126/science.aaz8995) In a new study, researchers from research institutions such as Shanghai University of Science and Technology, the University of Michigan and the University of Southern California have revealed an exact shape that plays a key role in human metabolism, which may open the door to obesity and other metabolic diseasesThey focused on the protein, called melanocortin 4 receptor, MC4R, and the study was published in the journal ScienceMC4R plays a vital role in regulating the body's energy balance by controlling how much energy is stored in the form of fatMutations in the gene that encode the MC4R protein are the most common genetic cause of early obesity, affecting about 1 in 1,500 peopleThe researchers were interested in MC4R as part of a larger effort to clarify the structure of G protein conjugal receptors (GPCR), where MC4R is a member of g-protein conjugate receptorsWhen they began working on the structure of MC4R, they sought the help of Roger Cone of the University of Michigan's Institute of Life Sciences and his colleagues2) PLoS Biol: It's scary! Cell pressure may cause obese women to give birth to obese offspring doi: 10.1371/journal.pbio.3000296 Does maternal obesity really increase the risk of obesity and body metabolism disorders in future generations? In a recent study published in the international journal PLoS Biology, scientists from the French National Institute of Health and Medical Research and others found that a key step in the process is induced pressure on the complex membrane system of the endothelial membrane, which leads to key changes in the development of the hypothalamus, a key part of the brain that controls hunger, satiety and metabolic ratesThe endosomein network, which plays a key role in protein synthesis and many other biological processes, activates a process called "unfolded protein response" that, under normal function, restores cell balance, but the prolongation of activation is often directly related to obesity-induced insulin tolerance and type 2 diabetes in adultsBecause of this association, as well as maternal obesity, or directly related to abnormal development of the hippocampus, the researchers wondered whether endosomeary network pressure was associated with obesity-induced hypothalamus changes3) Nanomedicine: Silicon dioxide particles may be used to treat obesity and diabetes doi: 10.2217/nnm-2019-0262 designed to identify methic silica particles (MSPs) as absorbable molecular traps, introduced into the intestines, can have an impact on food efficiency and metabolic risk factors; So far, there is no effective treatment for obesity, both to prevent weight gain and promote weight loss without having problematic side effectsMany current drugs use small pharmacological preparations that can have a negative impact on the body in many waysWe chose an innovative alternativeMesoporous silica particles (MSPs) are absorbable synthetic silicon dioxide particles that produce large surface areas and pores of different sizes, and the team hypothesized that they can be used as "molecular sieves" in the intestines to capture and block digestive enzymes that break down food, reducing the amount of energy intake (measured in food efficiency)In nanomedical reports, mice were fed high-fat, high-calorie foods to induce weight gain and mixed with specially designed MSPsThe results showed that MSPs reduced food efficiency by 33%, thereby reducing weight gain and having a positive impact on metabolism, while significantly reducing adipose tissue formation and leptin levels, and lowering circulating insulin levels4: Discover a new mechanism to prevent and reverse obesity: 10.1038/s41366-019-0512-z Obesity is a global epidemic that is known to be a cause of several cancers, including breast, colon and pancreatic cancers Stopping the obesity epidemic may be an important help in preventing and treating many cancers Researchers at Dartmouth University and Dr Craig Tomlinson's lab at Dartmouth-Hitmouth-Hitchbroke's Norris Cotton Cancer Center have identified a key target for the cause The team found that AHR, a receptor that exists in almost all cells, also plays an important role in the body's metabolism In the study mice, blocking AHR not only prevents obesity, but also reverses obesity, the team's findings were published recently in the journal International of Obesity The researchers said our experiments showed that when a drug called NF was added to a high-fat diet, mice were no fatter than those on a low-fat diet At the same time, mice without a high-fat diet without NF became very obese No adverse reactions were seen in the drug The team went on to prove that blocking AHR with NF not only prevents obesity, but also reverses it "In these experiments, we made mice fat at a high-fat diet, and half of the mice were converted to a high-fat diet containing the AHR blocker NF Over the next few weeks, mice who switched to a high-fat diet containing NF fell to the same weight as those on a low-fat diet The rest of the mice who ate high-fat foods became obese Sci Transl Med: A cancer-resistant compound or a compound that can help fight obesity and diabetes: 10.1126/scitranslmed.au5956, a recent study published in the international journal Science Translational Medicine, from Scientists at the University of New Mexico and others have found that a cancer-resistant compound called G-1 may help reduce the fat content of obese mice, and although G-1 is currently in phase 1 clinical trial for cancer, researchers are planning preclinical trials using G-1 to help fight fat in obese people Obesity affects the health of 40 percent of U.S adults and can lead to a variety of health problems, including heart disease, high blood pressure, type 2 diabetes and certain cancers Obesity and its related diseases far outnumber other causes of death in the population, and current drugs to treat obesity do not effectively curb obesity or have serious side effects 'We are currently working on GPER, a G-protein-linked estrogen receptor that is activated by G-1 because It affects specific breast cancer cells and activates GPER found in cell membranes when breast cancer drugs such as tamoxifen and fluorovirs block estrogen receptors in the nucleus of the cell,' said researcher Prossnitz Photo Credit: CC0 Public Domain 6 Food Chem Toxi: Can Coffee Beans Alleviate Obesity? Doi: 10.1016/j.fct.2019.110672 A recent study published in the Journal of Food and Chemical Toxicology showed that when mice's fat cells were treated with water-soluble extracts from the skin of coffee beans, two phenolic compounds (primary and non-edible acids) reduced fat inflammation, improved glucose and insulin absorption sensitivity The results suggest that eating these bioactive compounds as part of a diet could be used as a strategy to prevent obesity-related chronic diseases such as type 2 diabetes and cardiovascular disease 'We looked at bioactive compounds in different foods and saw their benefits in preventing chronic diseases, ' the researchers said "In this study, the researchers looked at the effects of two types of cells, macrophages and fat cells, as well as mixed compounds in extracts and individual phenols, on the production and metabolism of fat cells in the body, as well as on associated hormone sensitivity, and also looked at their effects on inflammatory responses 7(Ebiomedicine: New methods to help treat obesity and type 2 diabetes doi: 10.1016/j.ebiom.2019.07.069 A new study published in the journal EBioMedicine at King's College London found that a newly tested medical device can mimic the effects of traditional bariatric surgery on rodents and have a positive effect on weight, fatty liver and diabetes control The device, called "Sleeveballoon," is a device that binds balloons to a connected sleeve that covers the initial part of the small intestine Under general anaesthetic, it is inserted into the stomach and intestines through minimally invasive surgery In the study, researchers compared the effects of "balloon therapy" and traditional bariatric surgery on 30 high-fat diet rodents, with very positive results By using the new device, the animals' food intake was reduced by 60% and the amount of fat by 57% Blood sugar levels dropped by 65%, and the effect on diabetes was equally impressive 8 ( Gastroenterology ) New research shows that there is a trick in developing an anti-obesity vaccine! In a new study, researchers from Osaka Municipal University and the University of Tokyo in Japan reported that mice that were vaccinated against intestinal bacteria and ate a high-fat diet became less obese than those who were not vaccinated This is a step towards the development of a new anti-obesity vaccine The findings were recently published in the journal Gastroenterology Speaking about the significance of the study, the researchers said that by reducing specific types of gut bacteria, the findings could lead to the development of an anti-obesity vaccine that would allow people to eat without gaining weight The researchers focused on Clostridium ramosum, a common bacteria associated with obesity and diabetes In experiments with mice, the researchers developed a vaccine that activates the immune response in the intestinal mucosa They transplanted gut bacteria from obese individuals into pathogen-free mice The mice then ate a high-fat diet Cell Rep: Identify a new molecular mechanism to fight obesity: 10.1016/j.celrep.2019.07.101 The global obesity rate has nearly tripled since 1975, and in a recent study published in the international journal Cell Reports, scientists from the University of Minnesota found that key molecules involved in obesity can be developed or potentially reduced mutations to help develop new forms of obesity therapy Researcher Alessandro Bartolomucci said a key mutation in a peptide and its receptors, which are often involved in obesity, diabetes and high blood pressure, is critical to the multibiological activity of rodents, which may help develop possible treatment strategies for treating human-related diseases In previous studies, researchers found that the neuropeptides in mouse organisms called TLQP-21 activate C3aR1 receptors to induce body fat to break down and generate energy, and then began research on humans, they found that peptides in the human body are not very active in inducing the body's biological activity, and in human and mouse obesity, this biological pathway is quite conservative The researchers then continued to test for rodent peptides that carry human receptors and were able to observe certain biological effects, but their effects were not as strong as those that carry rodent receptors JAMA Network Open: Watch out! The obesity epidemic will slowly transfer cancer to the young population! Doi: 10.1001/jamanetwork.2019.9261, in a recent study published in the international journal JAMA Network Open, scientists from Case Western Reserve University analyzed data on the national incidence of disease sepsis from 2000 to 2016 and found that obesity-related cancers are currently associated with cancer (OACs, obesity-associated cancers) is moving among young people, who are generally more likely to diagnose these cancers among people over 65, most notably the higher incidence of non-Hispanic black and Hispanic women and men OACs, and the incidence of certain cancers has increased by 200-400 percent Researcher Siran Koroukian, who has more than 6 million cancer cases in the Monitoring Epidemiology and Final Outcomes (SEER) database, said: 'We are surprised that obesity-related cancers have now shifted to people aged 20-49, but most notably in people aged 50-64; (BioValleyBioon.com) Bio Valley For More Great Counts! Stay tuned!