Several articles focus on recent advances in antibiotic resistance research!

In this article, the small compilation of recent scientists in the field of antibiotic resistance research new progress, share to everyone! Photo Source: Cell: AI predicts powerful antibiotics from more than 100 million molecules, kills super-resistant bacteria doi: 10.1016/j.cell.2020.01.021 A groundbreaking machine learning method has identified powerful new antibiotics from more than 100 million molecules, including a molecule that can fight multiple bacteria -- including tuberculosis and strains that are thought to be incurableThe researchers say the antibiotic, called halicin, is the first to be discovered by artificial intelligenceAlthough artificial intelligence has previously been used to assist with parts of the antibiotic discovery process, they say this is the first time that it has identified a whole new class of antibiotics from scratch without using any human hypothesisThe study was led by Jim Collins, a synthetic biologist at the Massachusetts Institute of Technology in Cambridge, and published in the journal CellJacob Durrant, a computational biologist at the University of Pittsburgh in Pennsylvania, said the study is significantNot only did the team identify candidate molecules, he said, but they also tested promising molecules in animal experimentsMore importantly, this method can also be applied to other types of drugs, such as those used to treat cancer or neurodegenerative diseasesNature: Children's vaccination sorority or an important measure to combat the spread of global antibiotic resistance: 10.1038/s41586-020-2238-4 In a recent study published in the international journal Nature, scientists from the University of California, Etc., said in low- and middle-income countries Children are vaccinated or powerful tools to fight antibiotic resistance; now around the world, overuse of antibiotics is driving the spread of superbugs that have evolved to survive exposure to antibiotics, making humans more susceptible to diseases such as septicaemia and tuberculosis, while people in low- and middle-income countries are suffering from the important blows of antibiotic resistanceThe study found that the vaccination of two common vaccines, pneumococcal combined with the vaccine and rotavirus vaccine, may significantly reduce the incidence of acute respiratory infections and diarrhea among children in low- and middle-income countries, and the number of children receiving antibiotic therapy will be significantly reduced as the number of children with the disease or serious disease decreasesResearcher Joseph Lewnard says almost all countries have developed or are in the process of developing national action plans to combat the crisis posed by antibiotic resistance to the nhs, but there is little evidence of which interventions are effectiveBy providing precise figures on the substantial impact of using only the two vaccines, the researchers say vaccination may be expected to be one of the top prioritiesNature: Overturn the previous theory! New research reveals for the first time that the fine structure of bacterial cell walls is expected to completely solve the problem of antibiotic resistance! Doi: 10.1038/s41586-020-2236-6 In a recent study published in the international journal Nature, scientists from the University of Sheffield and others revealed the first high-resolution images of bacterial cell wall structures, the results of which shed light on the molecular mechanisms of antibiotic resistanceIn the article, the researchers revealed a new and important new structure of the bacterial outer membrane of Staphylococcus aureus, which is critical to understanding the mechanisms of bacterial growth and antibiotics, and overturns previous theories about the structure of bacterial outer membranes; the images obtained by the researchers help them gain insight into the composition of bacterial cell walls and do not develop new antibiotics to help ward off antibiotic resistanceResearcher Dr Laia Pasquina Lemonche says many antibiotics can play a role by inhibiting the production of bacterial cell walls, a strong but permeable outer membrane around the bacteria that is critical to the survival of bacteria; 4)Sci Adv: New antibiotics can treat multidrugresistant bacteria without side effects: 10.1126/sciadv.aay6817 In a recent study, researchers at the University of Pittsburgh Graduate School of Public Health significantly reduced the toxic side effects of potential antibiotics in the fight against drug-resistant bacterial infections, while also improving their stability against infectionIn the study, scientists targeted bacterial infections in the lungs of mice by administering the tracheaExperimental results show that the new antibiotic is more effective than other traditional methods of fighting drug-resistant bacteria, and has no obvious toxic side effectsThe results were published in the latest issue of The Journal of Science Advance In the United States, people die every 15 minutes from antibiotic-resistant infections This occurs when bacteria develop resistance to antibiotics rapidly, making them "superbugs" The experimental drug developed by the Institute is constructed from engineered cationanti-bacterial peptides or "eCAP", an optimized version of naturally synthesized antimicrobial peptides The team is working on an eCAP called WLBU2, owned by Peptilogics, which is undergoing clinical trials to prevent infections associated with knee and hip replacement surgery Researchers are looking for ways to make WLBU2 more stable so it can stay long enough to fight long-term lung infections Nat Commun: New strategy for combating antibiotic resistance doi: 10.1038/s41467-019-13660-x Bioscience engineers at the University of Leuven in Belgium have developed a new antimicrobial strategy to weaken bacteria by preventing bacteria from cooperating Unlike antibiotics, this strategy is not resistant because there are more drug-resistant bacteria than resistant bacteria The findings were published in the journal Nature Communications Traditional antibiotics kill or reduce the activity of individual bacteria Some bacteria become resistant to these antibiotics, allowing them to grow further and replace those that are not resistant As a result, the use of antibiotics has led to more and more bacteria becoming resistant to antibiotics However, bacteria also exhibit group behavior: for example, they can form a protective mucus layer or biofilm that wraps their entire bacterial community Dental plaque is an example of this biofilm Biofilms are usually the source of bacterial infections The social behavior of bacteria is an interesting new goal of antimicrobial therapy The researchers found that preventing salmonella from producing mucus weakens bacterial communities and makes them easier to remove They used a chemical antibacterial substance previously developed at the University of Kuruven "Without their protective mucus layer, bacteria can be mechanically washed away and more likely to be killed by antibiotics, disinfectants or the immune system," said Professor Steenackers of MICA Labs, the study's lead author Photo Credit: NIH 6Science: Shock! In a new study, researchers from the Hebrew University of Israel and the Shersydik Medical Center found evidence that combination antibiotic therapy for patients suffering from bacterial infections may promote the spread of drug resistance, published in the journal Science, entitled "Effect of the drug of the evolution of the evolution of the antibiotic s In this paper, they describe the study of patients who have been infected with bacterial infections and what they have learned Over the past few years, scientists have found that pathogenic bacteria have evolved to become resistant to many antibiotics For this reason, doctors have been giving patients multiple antibiotics in the hope that at least one of them will kill bacteria But in the long run, it could make things worse They found that this could lead to increased resistance to antibiotics in combination therapy To study the problem, the researchers studied a patient whose blood was infected with Staphylococcus aureus The patient was treated with vancomycin, but when the drug failed to suppress the infection, doctors joined rifampicin Eight days later, doctors replaced vancomycin with daptomycin While treating the patient, the researchers took blood samples to determine the effectiveness of the treatment, but this also allowed the researchers to test the bacteria individually or directly on the level of tolerance of all antibiotic drugs used to treat the patient Nature: New antibiotics can effectively kill drug-resistant bacteria doi: 10.1038/s41586-019-1791-1 More and more infectious bacterial pathogens are resistant to conventional antibiotics Some of these typical hospital-specific bacteria, such as E coli and Creebo pneumonia, have become resistant to most of the antibiotics currently available, and in some cases even to all antibiotics Institutionally, the outer membranes of these drug-resistant bacteria make them vulnerable to attack Recently, scientists from the University of Justinus Liebich (JLU) discovered a new type of peptide that can attack Gram-negative bacteria through previously unknown targets In the study, the researchers used screening methods commonly used in natural product studies and successfully isolated a peptide called Darobactin Darobactin consists of seven amino acids whose structural characteristics indicate that they are connected by a rare closed-loop After testing, the researchers confirmed that the substance was not cytotoxic, which is a prerequisite for any molecule to be used as an antibiotic The author of the article, Sch? "We now have a way of understanding how bacteria synthesize the molecule, " says Professor Berle We are conducting natural product research at the JLU Institute of Insect Biotechnology to increase the production of this substance and attempt to produce substances with similar structures Nat Microbiol: Antibiotic treatment or microbiome that alters the body of premature babies promotes the production of antibiotic-resistant intestinal flora: 10.1038/s41564-019-0550-2 In a recent study published in the international journal Nature Microbiology, scientists from the University of Washington School of Medicine found that treating premature babies for more than 20 months with antibiotics appears to promote the development of the body's multi-bacteria In the article, the researchers analyzed fecal samples from 32 babies, all premature, who were treated with antibiotics for 21 months, including in the neonatal intensive care unit and after discharge, while nine others were treated with antibiotics less than a week ago, and 17 healthy and late infants were not treated with antibiotics Infants treated with antibiotics for long periods of time have fewer types of bacteria in their guts than other infants, and these bacteria contain more antibiotic-resistant genes Science: Stunned! Antibiotic resistance in edible animals such as pork has nearly tripled since 2000! doi: 10.1126/science.aaw1944 In a recent study published in the international journal Science, scientists from institutions such as Princeton University found that growing demand for animal proteins in developing countries led to the heavy use of antibiotics in livestock, almost tripled antibiotic resistance that could easily spread from animals to humans In the article, researchers collected nearly 1,000 published and unpublished veterinary studies around the world, mapping antibiotic resistance in low- and middle-income countries, and focused on E coli, bentethromycin, salmonella and Staphylococcus aureus, all of which cause serious diseases in animals and humans The researchers found that from 2000 to 2018, the proportion of antibiotics resistant in developing countries, more than 50 percent, increased from 0.15 to 0.41 in chickens and 0.34 in pigs, meaning that antibiotics used for treatment were ineffective for more than half of the time in 40 percent of chickens and one-third of pigs consumed by humans Cell: Engineered phages can kill antibiotic-resistant pathogens: 10.1016/j.cell.2019.09.015 In the fight against bacterial antibiotic resistance, many scientists have been trying to use phage to infect and kill bacteria Phage kills bacteria differently than antibiotics, and they can target specific strains, making it a potential choice to overcome the problem of multiple drug resistance However, the rapid detection and optimization of clearly targeted bacteriophage "drugs" is challenging at present In a new study, mIT biology engineers show that they can quickly program phages to kill different types of E coli by mutating proteins bound to host cells In addition, the researchers found that these engineered phages are also less likely to cause bacterial resistance (BioValleyBioon.com) Bio Valley For More Great Counts! 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