Sesame opens the door -- new invention can carry drugs across the blood-brain barrier

February 8, 2015 / BIOON / -- the brain has a barrier of cells that can tightly regulate the transport of substances to prevent infection This barrier also causes 98% of drugs targeted at the central nervous system to turn red Recently, in the Journal Angewandte Chemie, scientists at Barcelona's biomedical research institute said they could find a "shuttle bus" that can cross the blood-brain barrier and transport various substances into the brain "It's estimated that at some point in the future, 20% of human beings will need brain specific therapeutic drugs," said researcher Meritxell teixid ó, leader of the research team "Many diseases have some good candidates, but they don't have the ability to reach their target organs Now we provide a solution to the urgent clinical needs The blood-brain barrier is not completely sealed The brain needs oxygen, iron, insulin, etc all the transport mechanisms enter the brain through a special "door" Researchers used retro - enantio to create a peptide that uses iron receptors to cross the blood-brain barrier without damaging nutrients or changing the protective function of the barrier The value of this peptide lies in two unique properties: it is small in size and has only 12 amino acids; it has a blood persistence of 12 to 24 hours Peptide, which has a half-life of just a few minutes in the blood, is resistant to protease, and therapeutic use is feasible - it does not need to take a drug every five minutes; in addition, the peptide can be mass produced The preliminary experiments in mice showed that the peptide had no immune response and low toxicity Researchers from different institutions have worked together on three rare or rare disease treatment programs Therapeutic antibodies including peptide binding are used to treat glioblastoma, and an innovative treatment for Friede's ataxia, a rare hereditary neurodegenerative disease, is studied This was done to introduce a gene vector loaded with the patient's lack, with a particular focus on the target neuron There are also clinical researchers working on making peptides shuttle into the blood-brain barrier to treat a pediatric brain tumor The invention has been patented The pharmaceutical industry is showing great interest Because many companies may re test potential molecules that have been discarded and link them to the shuttle peptide Maybe there will be a large number of new drugs for central nervous system diseases in the future This article is the original compilation of Biovalley, welcome to reprint! Please indicate the source of the reprint and attach the original link Thank you! DOI: 10.1002/anie.201411408 Applying the Retro-Enantio Approach to Obtain a Peptide Capable of Overcoming the Blood-Brain Barrier Roger Prades, Benjamí Oller-Salvia, Susanne M Schwarzmaier, Javier Selva, María Moros, Matilde Balbi, Valeria Grazffl, Jesus M de La Fuente, Gustavo Egea, Nikolaus Plesnila, Meritxell Teixidó, and Ernest Giralt Abstract The blood-brain barrier (BBB) is a formidable physical and enzymatic barrier that tightly controls the passage of molecules from the blood to the brain In fact, less than 2?% of all potential neurotherapeutics are able to cross it Here, by applying the retro-enantio approach to a peptide that targets the transferrin receptor, a full protease-resistant peptide with the capacity to act as a BBB shuttle was obtained and thus enabled the transport of a variety of cargos into the central nervous system.